The Presympathetic Cells of the Rostral Ventrolateral Medulla (RVLM): Anatomy, Physiology and Role in the Control of Circulation

  • Patrice G. Guyenet
  • Ruth L. Stornetta

Abstract

The ventrolateral aspect of the medulla oblongata (RVLM) contains presympathetic (PS) neurons that are highly active and receive strong inhibitory inputs from baroreceptors. These bulbospinal and barosensitive (BSBS) neurons are glutamatergic and express several other phenotypes including adrenergic (C1 cells). BSBS neurons selectively target sympathetic preganglionic neurons (SPGNs) that control the heart, kidney, adrenal medulla and the resistance vessels and are therefore essential for blood pressure maintenance and stabilization. In tissue slices, RVLM PS neurons display intrinsic beating properties that can be upregulated by slow transmitters such as angiotensin IL Glutamate, GABA and glycine are the best known mediators of fast synaptic transmission in these cells. Both glutamatergic and GABAergic inputs to BSBS neurons are regulated presynaptically by catecholamines, opioids and, probably, serotonin. The on-going activity of RVLM BSBS neurons in vivo is probably due to inotropic synaptic inputs and slow transmitters that upregulate the intrinsic beating properties of the cells. In vivo, RVLM BSBS neurons are subject to an intense GABAergic inhibitory tone indicating that dishinhibition could be crucial for the regulation of sympathetic tone. Mono or oligosynaptic inputs to BSBS neurons originate from numerous regions of the spinal cord, medulla oblongata, pons, midbrain and hypothalamus. The relative weight of these various inputs depends on the behavior or physiological status of the animal. Under anesthesia some of these brain regions are active causing excitation or disinhibition of RVLM BSBS neurons. Increased activity of RVLM BSBS neurons is suspected to contribute to the increased sympathetic tone associated with hypertension and, possibly, heart failure.

Key words

RVLM C1 adrenergic cells epinephrine neural control of circulation blood pressure medulla oblongata 

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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Patrice G. Guyenet
    • 1
  • Ruth L. Stornetta
    • 1
  1. 1.Department of PharmacologyUniversity of VirginiaCharlottesvilleUSA

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