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Serotonin Neurons in the Brainstem and Spinal Cord: Diverse Projections and Multiple Functions

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Neural Mechanisms of Cardiovascular Regulation

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Abstract

Serotonin neurons are located in the midline of the brainstem. The axons of these neurons branch profusely throughout the entire neuraxis providing an innervation to neurons that are involved in activities as diverse as the sleep/wake cycle, autonomic control and motor control. Here we review some of the work that has been done in relation to serotonin neurons in the brainstem with particular regard to the anatomy and co-localisation of other neurotransmitters. Particular attention is paid to the role of serotonin neurons in control of the cardiovascular system, but the role played by these neurons in modulating pain, chemosensation, thermoregulation and motor control as well as the sleep/wake cycle and sexual function is also dealt with. We conclude that despite considerable work in the past, much remains to be learned about the serotonin containing neurons and the other neurotransmitters that are released from these aminergic neurons.

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  1. Departments of Physiology and Neurosurgery, University of Sydney and Royal North Shore Hospital, Sydney, Australia

    Paul M. Pilowsky

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  1. Temple University School of Medicine, Philadelphia, PA, USA

    Nae J. Dun Ph.D.

  2. School of Medicine of Ribeirão Preto, University of São Paulo, Brazil

    Benedito H. Machado Ph.D.

  3. Faculty of Medicine, University of Sydney, Australia

    Paul M. Pilowsky B.M.B.S., Ph.D.

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Pilowsky, P.M. (2004). Serotonin Neurons in the Brainstem and Spinal Cord: Diverse Projections and Multiple Functions. In: Dun, N.J., Machado, B.H., Pilowsky, P.M. (eds) Neural Mechanisms of Cardiovascular Regulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9054-9_10

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