Role of the T-System and the Na-K Pump on Fatigue Development in Phasic Skeletal Muscle

  • Hugo Gonzalez-Serratos
  • Ruzhang Chang
  • Monika Rozycka
  • Mordecai Blaustein
  • Patrick DeDeyne
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 538)


Prolonged, direct electrical stimulation of vertebrate skeletal muscles induces a state during which contractile force or the capacity to do external work declines after prolonged repetitive stimulation. The muscles then become fatigued or mechanically refractory to further stimulation. Fatigue does not involve permanent impairment of function since contractility can be restored. It is not due to neuromuscular transmission failure1 nor is it caused by a decline in the central nervous system motor drive of muscle. Fatigue is due solely to contractile failure2, 3.


Myosin Heavy Chain Extensor Digitorum Longus Fatigue Index Tetanic Tension Fatigue Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Hugo Gonzalez-Serratos
    • 1
  • Ruzhang Chang
    • 1
  • Monika Rozycka
    • 1
  • Mordecai Blaustein
    • 1
  • Patrick DeDeyne
    • 1
  1. 1.Department of PhysiologyUniversity of Maryland, School of MedicineBaltimoreBaltimore

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