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Myosin-Binding Protein C (MyBP-C) in Cardiac Muscle and Contractility

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 538)

Abstract

Myosin binding protein C (MyBP-C) was first discovered in skeletal muscle by Offer et al, (1973), and subsequent work from several laboratories (Koretz 1979, Craig and Offerl976, Davies 1988, Sciler et al 1996, Sebillon et al 2001) has shown that it can play an important role in the formation of normal thick filaments in skeletal muscle. In its absence, isolated myosin does not form thick filaments with uniform thickness, uniform length or helically ordered myosin heads (Koretz 1079, Rhee et al 1994, Lin et al 1994). Surprisingly, cardiac muscle from mice with MyBP-C knocked out form normally appearing sarcomeres and myofibrils (Harris et al 2002), raising the possibility that some form of compensation has occurred or formation of thick filaments differs between cardiac and skeletal muscle.

Keywords

Cardiac Muscle Thin Filament Myosin Head Layer Line Thick Filament 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  1. 1.Saul Winegrad, Department of PhysiologySchool of Medicine, University of PennsylvaniaPhiladelphiaUSA

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