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Function of the transporter associated with antigen processing (TAP) in cellular immunity, tumor escape, and virus persistence

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Membrane Transporter Diseases

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Abstract

The transporter associated with antigen processing (TAP) plays a pivotal role in the cellular immune response. The heterodimeric transporter complex translocates peptides derived from endogenous proteins from the cytosol into the endoplasmic reticulum (ER). This transport is a requirement for subsequent peptide presentation on the cell surface. Viral and tumor-specific peptides can be recognized by cytotoxic T lymphocytes (CTL), which subsequently kill the infected or tumorigenic cells. Furthermore, surface -exposed major histocompatibility complex (MHC) I molecules may stimulate the activity of natural killer (NK) cells and γδ T cells, which are also involved in the elimination of virus-infected and malignant cells. On the other hand, viruses have evolved sophisticated mechanisms to escape immune recognition by impairing antigen presentation, for example, on the level of TAP-mediated peptide transport.

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References

  • Ahn, K., Meyer, T.H., Uebel, S., Sempe, P., Djaballah, H., Yang, Y, et al. (1996). Molecular Mechanism and Species Specificity of TAP Inhibition by Herpes Simplex Virus ICP47. EMBO J., 15, 3247–3255.

    PubMed  CAS  Google Scholar 

  • Ahn, K., Gruhler, A., Galocha, B., Jones, TR., Wiertz, EJ., Ploegh, H.L., et al. (1997). The ER-Luminal Domain of the HCMV Glycoprotein US6 Inhibits Peptide Translocation by TAP. Immunity, 6, 613–621.

    Article  PubMed  CAS  Google Scholar 

  • Alberts, P., Daumke, O., Deverson, E.V., Howard, J.C., and Knittler, M.R. (2001). Distinct Functional Properties of the TAP Subunits Coordinate the Nucleotide-Dependent Transport Cycle. Curr Biol., 11, 242–251.

    Article  PubMed  CAS  Google Scholar 

  • Aleksandrov, L., Alcksandrov, A.A., Chang, X.B., and Riordan, J.R. (2002). The First Nucleotide Binding Domain of Cystic Fibrosis Transmembrane Conductance Regulator is a Site of Stable Nucleotide Interaction, whereas the Second is a Site of Rapid Turnover. J. Biol. Chem., 277, 15419–15425.

    Article  PubMed  CAS  Google Scholar 

  • Alimonti, J., Zhang, Q.J., Gabathuler, R., Reid, G., Chen, S.S., and Jefferies, W.A. (2000). TAP Expression Provides a General Method for Improving the Recognition of Malignant Cells In Vivo. Nat. Biotechnol., 18, 515–520.

    Article  PubMed  CAS  Google Scholar 

  • Andersson, M., Paabo, S., Nilsson, T., and Peterson, P.A. (1985). Impaired Intracellular Transport of Class I MHC Antigens as a Possible Means for Adenoviruses to Evade Immune Surveillance. Cell, 43, 215–222.

    Article  PubMed  CAS  Google Scholar 

  • Antoniou, A.N., Ford, S., Alphey, M., Osborne, A., Elliott, T. and Powis, S.J. (2002). The Oxidoreductase ERpS7 Efficienly Reduces Partially Folded in Preference to Fully Folded MHC Class I Molecules. EMBO J., 21, 2655–2663.

    Article  PubMed  CAS  Google Scholar 

  • Arons, E., Kunin, V., Schechter, C., and Ehrlich, R. (2001). Organization and Functional Analysis of the Mouse Transporter Associated with Antigen Processing 2 Promoter. J. Immunol., 166, 3942–3951.

    PubMed  CAS  Google Scholar 

  • Arora, S., Lapinski, P.E., and Raghavan, M. (2001). Use of Chimeric Proteins to Investigate the Role of Transporter Associated with Antigen Processing (TAP) Structural Domains in Peptide Binding and Translocation. Proc. Natl Acad. Sci USA, 98, 7241–7246.

    Article  PubMed  CAS  Google Scholar 

  • Baumeister, W., Walz, J., Zühl, F., and Seemuller, E. (1998). The Proteasome: Paradigm of a SelfCompartmentalizing Protease. Cell, 92, 367–380.

    Article  PubMed  CAS  Google Scholar 

  • Belich, M.P., Glynne, R.J., Senger, G., Sheer, D., and Trowsdale, J. (1994). Proteasome Components with Reciprocal Expression to that of the MHC-Encoded LMP Proteins. Curr Biol., 4, 769–776.

    Article  PubMed  CAS  Google Scholar 

  • Beninga, J., Rock, K.L., and Goldberg, A.L. (1998). Interferon-Gamma can Stimulate Post-Proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase. J. Biol. Chem., 273, 18734–18742.

    Article  PubMed  CAS  Google Scholar 

  • Bennett, E.M., Bennink, J.R., Yewdell, J.W., and Brodsky, F.M. (1999). Cutting Edge: Adenovirus E19 has Two Mechanisms for Affecting Class I MHC Expression. J. Immunol., 162, 5049–5052.

    PubMed  CAS  Google Scholar 

  • Bernaerts, A., Vandevenne, J.E., Lambert, J., de Clerck, L.S., and de Schepper, A.M. (2001). Bare Lymphocyte Syndrome: Imaging Findings in an Adult. Eur. Radial., 11, 815–818.

    Article  CAS  Google Scholar 

  • Brander, C., Suscovich, T., Lee, Y., Nguyen, P.T., O’Connor, P., Seebach, J., et al. (2000). Impaired CTL Recognition of Cells Latently Infected with Kaposi’s Sarcoma-Associated Herpes Virus. J. Immunol., 165, 2077–2083.

    PubMed  CAS  Google Scholar 

  • Burgert, H.G., and Kvist, S. (1985). An Adenovirus Type 2 Glycoprotein Blocks Cell Surface Expression of Human Histocompatibility Class I Antigens. Cell, 41, 987–997.

    Article  PubMed  CAS  Google Scholar 

  • Burgert, H.G. and Kvist, S. (1987). The E3/l9K Protein of Adenovirus Type 2 Binds to the Domains of Histocompatibility Antigens Required for CTL Recognition. EMBO J., 6, 2019–2026.

    PubMed  CAS  Google Scholar 

  • Chen, C.J., Chin, J.E., Ueda, K., Clark, D.P., Pastan, I., Gottesman, M.M., et al. (1986). Internal Duplication and Homology with Bacterial Transport Proteins in the mdrI (P-glycoprotein) Gene from Multidrug-Resistant Human Cells. Cell, 47, 381–389.

    Article  PubMed  CAS  Google Scholar 

  • Chen, H.L., Gabrilovich, D., Tampe, R., Girgis, K.R., Nadaf, S., and Carbone, D.P. (1996). A Functionally Defective Allele of TAP1 Results in Loss of MHC Class I Antigen Presentation in a Human Lung Cancer. Nat. Genet., 13, 210–213.

    Article  PubMed  CAS  Google Scholar 

  • Colonna, M., Bresnahan, M., Bahram, S., Strominger, J.L., and Spies, T. ( 1992). Allelic Variants of the Human Putative Peptide Transporter Involved in Antigen Processing. Proc. Natl Acad. Sci. USA, 89, 3932–3936.

    Article  PubMed  CAS  Google Scholar 

  • Corrias, M.V., Occhino, M., Croce, M., De Arnbrosis, A., Pistillo, M.P., Bocca, P., et al., (2001). Lack of HLAClass I Antigens in Human Neuroblastoma Cells: Analysis of its Relationship to TAP and Tapasin Expression. Tissue Antigens, 57, 110–117.

    Article  PubMed  CAS  Google Scholar 

  • Cramer, L.A., and Klemsz, M.J. (1997). Altered Kinetics of Tap-1 Gene Expression in Macrophages Following Stimulation with both IFN-Gamma and LPS. Cell Immunol., 178, 53–61.

    Article  PubMed  CAS  Google Scholar 

  • Cromme, F.V., Airey, J., Hcemels. M.T., Ploegh, H.L., Keating, P.J., Stern, P.L., et al. (1994). Loss of Transporter Protein, Encoded by the TAP-1 Gene, is Highly Correlated with Loss of HLA Expression in Cervical Carcinomas. J. Exp. Med., 179, 335–340.

    Article  PubMed  CAS  Google Scholar 

  • Daniel, S., Caillat-Zucman, S., Hammer, J., Bach, J.F, and van Endert, P.M. (1997). Absence of Functional Relevance of Human Transporter Associated with Antigen Processing Polymorphism for Peptide Selection. J. Immunol., 159, 2350–2357.

    PubMed  CAS  Google Scholar 

  • Daumke, O., and Knittler, M.R. (2001). Functional Asymmetry of the ATP-Binding-Cassettes of the ABC Transporter TAP is Determined by Intrinsic Properties of the Nucleotide Binding Domains. Eur: J. Biochem., 268, 4776–4786.

    Article  CAS  Google Scholar 

  • de la Salle, H., Hanau, D., Fricker, D., Urlacher, A., Kelly, A., Salamero, J., et al. (1999). Homozygous Human TAP Peptide Transporter Mutation in HLA Class I Deficiency. Science, 265, 237–241.

    Article  Google Scholar 

  • de la Salle, H., Zimmer, J., Fricker, D., Angenieux, C., Cazenave, J.P., Okubo, M., et al. (1999). HLA Class I Deficiencies due to Mutations in Subunit 1 of the Peptide Transporter TAP1. J. Clin. Invest., 103, R9–R13.

    Article  PubMed  Google Scholar 

  • Diedrich, G., Bangia, N., Pan, M., and Cresswell, P. (2001). A Role for Calnexin in the assembly of the MHC Class I Loading Complex in the Endoplasmic Reticulum. J. Immunol., 166, 1703–1709.

    PubMed  CAS  Google Scholar 

  • Driscoll, J., Brown, M.G., Finley, D., and Monaco, J.J. (1993). MHC-Linked LMP Gene Products Specifically Alter Peptidase Activities of the Proteasome. Nature, 365, 262–264.

    Article  PubMed  CAS  Google Scholar 

  • Ehring, B., Meyer, T.H., Eckerskorn, C., Lottspeich, F., and Tarnpé, R. (1996). Effects of Major-Histocompatibility Complex-Encoded Subunits on the Peptidase and Proteolytic Activities of Human 20S Proteasomes. Cleavage of Proteins and Antigenic Peptides. Eur. J. Biochem., 235, 404–415.

    Article  PubMed  CAS  Google Scholar 

  • Epperson, D.E., Arnold, D., Spies, T., Cresswell, P., Pober, J.S., and Johnson, D.R. (1992). Cytokines Increase Transporter in Antigen Processing-1 Expression More Rapidly than HLA Class I Expression in Endothelial Cells. J. Immunol., 149, 3297–3301.

    PubMed  CAS  Google Scholar 

  • Farrell, H.E., Vally, H., Lynch, D.M., Fleming, P., Shellam, G.R., Scalzo, A.A., et al. (1997). Inhibition of Natural Killer Cells by a Cytomegalovirus MHC Class I Homologue In Vivo. Nature, 386, 510–514.

    Article  PubMed  CAS  Google Scholar 

  • Früh, K., Ahn, K., Djaballah, H., Sernpé, P., van Endert, P.M., Tampé, R., Peterson, P.A., and Yang, Y. (1995). A viral inhibitor of peptide transporters for antigen presentation. Nature, 375, 415–418.

    Article  PubMed  Google Scholar 

  • Früh, K., and Yang, Y. (1999). Antigen Presentation by MHC Class I and its Regulation by Interferon Gamma. Curr. Opin. Immunol., 11, 76–81.

    Article  Google Scholar 

  • Furukawa, H., Murata, S., Yabe, T., Shirnbara, N., Keicho, N., Kashiwase, K., et al. (1999). Splice Acceptor site Mutation of the Transporter Associated with Antigen Processing-1 Gene in Human Bare Lymphocyte Syndrome. J. Clin. Invest., 103, 755–758.

    Article  PubMed  CAS  Google Scholar 

  • Gadola, S.D., Moins-Teisserenc, H.T., Trowsdale, J., Gross, W.L., and Cerundolo, V. (2000). TAP Deficiency Syndrome. Clin. Exp. Immunol., 121, 173–178.

    Article  PubMed  CAS  Google Scholar 

  • Gao, B., Adhikari, R., Howarth, M., Nakamura, K., Gold, M.C., Hill, A.B., et al. (2002). Assembly and Antigen-Presenting Function of MHC Class I Molecules in Cells Lacking the ER Chaperone Calreticulin. Immunity, 16, 99–109.

    Article  PubMed  CAS  Google Scholar 

  • Garboczi, D.N., Ghosh, P., Utz, U., Fan, Q.R., Biddison, W.E., and Wiley, D.C. (1996). Structure of the Complex between Human T-Cell Receptor, Viral Peptide and HLA-A2. Nature, 384, 134–141.

    Article  PubMed  CAS  Google Scholar 

  • Garrido, F., Ruiz-Cabello, E, Cabrera, T., Perez-Villar, J.J., Lopez-Botet, M., Duggan-Keen, M., et al. (1997). Implications for Immunosurveillance of Altered HLA Class I Phenotypes in Human Tumours. mmunol. Today, 18, 89–95.

    Article  CAS  Google Scholar 

  • Goldberg, A.L. and Rock, K.L. (1992). Proteolysis, Proteasomes and Antigen Presentation. Nature, 357, 375–379.

    Article  PubMed  CAS  Google Scholar 

  • Gorbulev, S., Abele, R., and Tarnpé, R. (2001). Allosteric Crosstalk between Peptide-Binding, Transport, and ATP Hydrolysis of the ABC Transporter TAP. Proc. Natl Acad. Sci. USA, 98, 3732–3737.

    Article  PubMed  CAS  Google Scholar 

  • Groettrup, M., Kraft, R., Kostka, S., Standera, S., Stohwasser, R., and Kloetzel, P.M. (1996). A Third Interferon-Gamma-Induced Subunit Exchange in the 20S Proteasome. Eur. J. Immunol., 26, 863–869.

    Article  PubMed  CAS  Google Scholar 

  • Guo, Y., Yang, T., Liu, X., Lu, S., Wen, J., Durbin, J.E., et al. (2002). Cis Elements for Transporter Associated with Antigen-Processing-2 Transcription: Two New Promoters and an Essential Role of the IFN Response Factor Binding Element in IFN-Gamma-Mediated Activation of the Transcription Initiator. Int. Immunol., 14, 189–200.

    Article  PubMed  CAS  Google Scholar 

  • Hanson, I.M. and Trowsdale, J. (1991). Colinearity of Novel Genes in the Class II Regions of the MHC in Mouse and Human. Immunogenetics, 34, 5–11.

    Article  PubMed  CAS  Google Scholar 

  • Harty, J.T., and Bevan, M.J. (1999). Responses of CD8(+) T Cells to Intracellular Bacteria. Curr. Opin. Immunol., 11, 89–93.

    Article  PubMed  CAS  Google Scholar 

  • Hengel, H., Koopmann, J.O., Flohr, T., Muranyi, W., Goulmy, E., Hämmerling, G.J., Koszinowski, U.H., and Momburg, F (1997). A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter. Immunity, 6, 623–632.

    Article  PubMed  CAS  Google Scholar 

  • Hengel, H., Reusch, U., Geginat, G., Holtappels, R., Ruppert, T., Hellebrand, E., et al. (2000). Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus. J. Virol., 74, 7861–7868.

    Article  PubMed  CAS  Google Scholar 

  • Hewitt, E.W., Gupta, S.S., and Lehner, P.J. (2001). The Human Cytomegalovirus Gene Product US6 Inhibits ATP Binding by TAP. EMBO J., 20, 387–396.

    Article  PubMed  CAS  Google Scholar 

  • Hill, A., Jugovic, P., York, J., Russ, G., Bennink, J., et al. (1995). Herpes Simplex Virus Turns Off the TAP to Evade Host Immunity. Nature, 375, 411–415.

    Article  PubMed  CAS  Google Scholar 

  • Jackson, D.G. and Capra, J.D. (1993). TAP1 Alleles in Insulin-Dependent Diabetes Mellitus: A Newly Defined Centromeric Boundary of Disease Susceptibility. Proc. Natl Acad. Sci. USA, 90, 11079–11083.

    Article  PubMed  CAS  Google Scholar 

  • Johnsen, A.K., Templeton, D.J., Sy, M., and Harding, C.V. (1999). Deficiency of Transporter for Antigen Presentation (TAP) in Tumor Cells Allows Evasion of Immune Surveillance and Increase s Tumorigenesis. J. Immunol., 163, 4224–4231.

    PubMed  CAS  Google Scholar 

  • Jones, T.R., Wiertz, E.J., Sun, L., Fish, K.N., Nelson, J.A., and Ploegh, H.L. (1996). Human Cytomegalovirus US3 Impairs Transport and Maturation of Major Histocompatibility Complex Class I Heavy Chains. Proc. Natl Acad. Sci. USA, 93, 11327–11333.

    Article  PubMed  CAS  Google Scholar 

  • Kageshita, T., Hirai, S., Ono, T., Hicklin, D.J., and Ferrone, S. (1999). Down-Regulati on of HLA Class I Antigen-Processing Molecules in Malignant Melanoma: Association with Disease Progression. Am. J. Pathol., 154, 745–754.

    Article  PubMed  CAS  Google Scholar 

  • Kaklamanis, L., Leek, R., Koukourakis, M., Gatter, K.C., and Harris, A.L. (1995). Loss of Transporter in Antigen Processing I Transport Protein and Major Histocompatibility Complex Class I Molecules in Metastatic versus Primary Breast Cancer. Cancer Res., 55. 5191–5194.

    PubMed  CAS  Google Scholar 

  • Kamarashev, J., Ferrone, S., Seifert, B., Boni, R., Nestle, F.O., Burg, G., et al. (2001). TAP1 Down Regulation in Primary Melanoma Lesions: An Independent Marker of Poor Prognosis. Int. J. Cancer, 95, 23–28.

    Article  PubMed  CAS  Google Scholar 

  • Kaufmann, S.H. (1993). Immunity to Intracellular Bacteria. Annu. Rev. Immunol., 11, 129–163.

    Article  PubMed  CAS  Google Scholar 

  • Kisselev, A.F, Akopian, T.N., Woo, K.M., and Goldberg, A.L. (1999). The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes. Implications for Understanding the Degradative Mechanism and Antigen Presentation. J. Biol. Chem., 274, 3363–3371.

    Article  PubMed  CAS  Google Scholar 

  • Klein, C., Lisowska-Grospierre, B., LeDeist, F., Fischer, A., and Griscelli, C. (1993). Major Histocompatibility Complex Class II Deficiency: Clinical Manifestations, Immunologic Features, and Outcome. J. Pediatr., 123, 921–928.

    Article  PubMed  CAS  Google Scholar 

  • Kloctzel, P.M. (2001). Antigen Processing by the Proteasome. Nat. Rev. Mol. Cell. Biol., 2, 179–187.

    Article  Google Scholar 

  • Knittler, M.R., Alberts, P., Deverson, E.V., and Howard, J.C. (1999). Nucleotide Binding by TAP Mediates Association with Peptide and Release of Assembled MHC Class I Molecules. Curr. Biol., 9, 999–1008.

    Article  PubMed  CAS  Google Scholar 

  • Komlosh, A., Momburg, F, Weinschenk, T., Emmerich, N., Schild, H., Nadav, E., et al. (2001). A Role for a Novel Luminal Endoplasmic Reticulum Aminopeptidase in Final Trimming of 26 S Proteasome-Generated Major Histocompatability Complex Class I Antigenic Peptides. J. Biol. Chem., 276. 30050–30056.

    Article  PubMed  CAS  Google Scholar 

  • Konno, Y., Numaga, J., Mochizuki, M., Mitsui, H., Hirata, R., and Maeda, H. (1998). TAP Polymorphism is not Associated with Ankylosing Spondylitis and Complications with Acute Anterior Uveitis in HLAB27-Positive Japanese. Tissue Antigens, 52. 478–483.

    Article  PubMed  CAS  Google Scholar 

  • Korkolopoulou, P., Kaklamanis, L., Pezzella, F., Harris, A.L., and Gatter, K.C. (1996). Loss of Antigen Presenting Molecules (MHC Class I and TAP-1) in Lung Cancer. Br. J. Cancer, 73, 148–153.

    Article  PubMed  CAS  Google Scholar 

  • Kruh, G.D., Zeng, H., Rea. P.A., Liu, G., Chen. Z.S., Lee, K., et al. (2001). MRP Subfamily Transporters and Resistance to Anticancer Agents. J. Bioenerg. Biomembr., 33. 493–501.

    Article  PubMed  CAS  Google Scholar 

  • Kyritsis, C., Gorbulev, S., Hutschenreiter, S., Pawlitschko, K., Abele, R., and Tampé, R. (2001). Molecular Mechanism and Structural Aspects of Transporter Associated with Antigen Processing Inhibition by the Cytomegalovirus Protein US6. J. Biol. Chem., 276, 48031–48039.

    PubMed  CAS  Google Scholar 

  • Lankat-Buttgereit, B. and Tarnpé, R. (2002). The Transporter Associated with Antigen Processing: Function and Implications in Human Diseases. Physiol. Rev., 82. 187–204.

    PubMed  CAS  Google Scholar 

  • Lee, H.J., Ha, S.J., Han, H., and Kim, J.W. (2001). Distribution of HLA-A. B Alleles and Polymorphisms of TAP and LMP Genes in Korean Patients with Atopic Dermatitis. Clin. Exp. Allergy. 31, 1867–1874.

    Article  PubMed  CAS  Google Scholar 

  • Lehner, P.J., Karttunen, J.T., Wilkinson. G.W., and Cresswell, P. (1997). The Human Cytomegalovirus US6 Glycoprotein Inhibits Transporter Associated with Antigen Processing-Dependent Peptide Translocation. Proc. Natl Acad. Sci. USA, 94. 6904–6909.

    Article  PubMed  CAS  Google Scholar 

  • Ljunggren, H.G. and Karre, K. (1990). In Search of the ‘Missing Self’: MHC Molecules and NK Cell Recognition. Immunol. Today, 11. 237–244.

    Article  PubMed  CAS  Google Scholar 

  • Maeurer, M.J., Gollin, S.M., Martin, D., Swaney, W., Bryant, J., Castelli, C., et al. (1996). Tumor Escape from Immune Recognition: Lethal Recurrent Melanoma in a Patient Associated with Downregulation of the Peptide Transporter Protein TAP-1 and Loss of Expression of the Immunodominant MART-1/Melan-A Antigen. J. CLIN Invest., 98. 1633–1641.

    Article  PubMed  CAS  Google Scholar 

  • Marincola, F.M., Shamamian. P., Alexander. R.B., Gnarra, J.R., Turetskaya, R.L., Nedospasov, S.A., et al. (1994). Loss of HLA Haplotype and B Locus Down Regulation in Melanoma Cell Lines. J. Immunol., 153. 1225–1237.

    PubMed  CAS  Google Scholar 

  • Matsuo. M., Kioka, N., Amachi, T., and Ueda. K. (1999). ATP Binding Properties of the Nucleotide-Binding Folds of SUR1. J. Biol. Chem., 274. 37479–37482.

    Article  PubMed  CAS  Google Scholar 

  • Matsuo, M., Tanabe. K., Kioka, N., Amachi, T., and Ueda, K. (2000). Different Binding Properties and Affinities for ATP and ADP among Sulfonylurea Receptor Subtypes. SUR1. SVR2A. and SUR2B. J. Biol. Chem., 275. 28757–28763.

    Article  PubMed  CAS  Google Scholar 

  • Moins-Teisserenc, H.T., Gadola, S.D., Cella, M., Dunbar. P.R., Exley, A., Blake. N., et al. (1999). Association of a Syndrome resembling Wegener’s Granulomatosis with Low Surface Expression of HLA Class-I Molecules. Lancet, 354, 1598–1603.

    Article  PubMed  CAS  Google Scholar 

  • Nandi, D., Jiang. H., and Monaco, J.J. (1996). Identification of MECL-1 (LMP-10) as the Third IFNGamma-Inducible Proteasome Subunit. J. Immunol., 156. 2361–2364.

    PubMed  CAS  Google Scholar 

  • Nijenhuis, M. and Hämmerling, G.J. (1996). Multiple Regions of the Transporter Associated with Antigen Processing (TAP) Contribute to its Peptide Binding Site. J. lmmunol., 157, 5467–5477.

    CAS  Google Scholar 

  • Obst, R., Armandola, E.A., Nijenhuis, M., Mornburg, F., and Hămmerling, G.J. (1995). TAP Polymorphism does not Influence Transport of Peptide Variants in Mice and Humans. Eur: J. Immunol., 25, 2170–2176.

    Article  CAS  Google Scholar 

  • Ohashi. P.S. (1996). T Cell Selection and Autoimmunity: Flexibility and Tuning. Curr: Opin. Immunol., 8, 808–814.

    Article  CAS  Google Scholar 

  • Pamer, E. and Cresswell, P. (1998). Mechanisms of MHC Class I-Restricted Antigen Processing. Annu. Rev. Immunol., 16, 323–358.

    Article  PubMed  CAS  Google Scholar 

  • Pfänder, R., Neumann. L., Zweckstetter, M., Seger, C., Holak, T.A., and Tarnpé, R. (1999). Structure of the Active Domain of the Herpes Simplex Virus Protein ICP47 in Water/Sodium Dodecyl Sulfate Solution Determined by Nuclear Magnetic Resonance Spectroscopy. Biochemistry, 38, 13692–13698.

    Article  PubMed  CAS  Google Scholar 

  • Ploegh, H.L. (1998). Viral Strategies of Immune Evasion. Science, 280, 248–253.

    Article  PubMed  CAS  Google Scholar 

  • Powis, S.H., Mockridge, I., Kelly, A., Kerr, L.A., Glynne, R., Gileadi, U., et al. (1992). Polymorphism in a Second ABC Transporter Gene Located within the Class II Region of the Human Major Histocompatibility Complex. Proc. Natl Acad. Sci. USA, 89. 1463–1467.

    Article  PubMed  CAS  Google Scholar 

  • Raghavan, M. (1999). Immunodeficiency due to Defective Antigen Processing: The Molecular Basis for Type 1 Bare Lymphocyte Syndrome. J. Clin. Invest., 103, 595–596.

    Article  PubMed  CAS  Google Scholar 

  • Restifo, N.P., Esquivel. F., Kawakami, Y., Yewdell, J.W., Mule, J.J., Rosenberg, S.A., et al. (1993). Identification of Human Cancers Deficient in Antigen Processing. J. Exp. Med., 177, 265–272.

    Article  PubMed  CAS  Google Scholar 

  • Reyburn, H.T., Mandelboim, O., Vales-Gomez, M., Davis. D.M., Pazmany. L., and Strorninger, J.L. (1997). The Class I MHC Homologue of Human Cytomegalovirus Inhibits Attack by Natural Killer Cells. Nature, 386, 514–517.

    Article  PubMed  CAS  Google Scholar 

  • Ritz. U., Momburg, F., Pircher, H.P., Strand. D., Huber. C., and Seliger, B. (2001). Identification of Sequences in the Human Peptide Transporter Subunit TAP1 Required for Transporter Associated with Antigen Processing (TAP) Function. Int. Immunol., 13. 31–41.

    Article  PubMed  CAS  Google Scholar 

  • Rock, K.L. and Goldberg, A.L. (1999). Degradation of Cell Proteins and the Generation of MHC Class I Presented Peptides. Annu. Rev. Immunol., 17, 739–779.

    Article  PubMed  CAS  Google Scholar 

  • Russ, G., Esquivel, F., Yewdell, J.W., Cresswell. P., Spies. T., and Bennink. J.R. (1995). Assembly. Intracellular Localization. and Nucleotide Binding Properties of the Human Peptide Transporters TAP1 and TAP2 Expressed by Recombinant Vaccinia Viruses. J. Biol. Chem., 270. 21312–21318.

    Article  PubMed  CAS  Google Scholar 

  • Saulquin, X., Bodinicr, M., Peyrar, M.A., Hislop, A., Scotet, E., Lang, F., et al. (2001). Frequent Recognition of BCRF1. a Late Lytic Cycle Protein of Epstein-Barr Virus. in the HLA-B*2705 Context: Evidence for a TAP-Independent Processing. Eur. J. Immunol., 31, 708–715.

    Article  PubMed  CAS  Google Scholar 

  • Seliger, B., Maeurer, M.J., and Ferrone. S. (1997). TAP Off — Tumors On. Immunol. Today, 18, 292–299.

    PubMed  CAS  Google Scholar 

  • Seliger, B., Maeurer, M.J., and Ferrone, S. (2000). Antigen-Processing Machinery Breakdown and Tumor Growth. Immunol. Today, 21, 455–464.

    Article  PubMed  CAS  Google Scholar 

  • Seliger, B., Bock, M., Ritz. U., and Huber, C. (2002a). High Frequency of a Non-functional TAPl/LMP2 Promoter Polymorphism in Human Tumors. Int. J. Oncol., 20, 349–353.

    PubMed  CAS  Google Scholar 

  • Seliger, B., Cabrera, T., Garrido, F., and Ferrone, S. (2002b). HLA Class I Antigen Abnormalities and Immune Escape by Malignant Cells. Semin. Cancer Biol., 12, 3–13.

    Article  PubMed  CAS  Google Scholar 

  • Seliger, B., Ritz, U., Abele, R., Bock, M., Tampé, R., Sutter, G., et al. (2001). Immune Escape of Melanoma: First Evidence of Structural Alterations in Two Distinct Components of the MHC Class I Antigen Processing Pathway. Cancer Res., 61, 8647–8650.

    PubMed  CAS  Google Scholar 

  • Shen, L., Chiang, A.K., Liu, W.P., Li, G.D., Liang, R.H., and Srivastava, G. (2001). Expression of HLA Class I, Beta(2)-Microglobulin, TAP 1 and IL-10 in Epstein-Barr Virus-Associated Nasal NK/T-Cell Lymphoma: Implications for Tumor Immune Escape Mechanism. Int. J. Cancer, 92, 692–696.

    Article  PubMed  CAS  Google Scholar 

  • Singal, D.P., Ye, M., Ni, J., and Snider, D.P. (1996). Markedly Decreased Expression of TAP 1 and LMP2 Genes in HLA Class I-Deficient Human Tumor Cell Lines. Immunol. Lett., 50, 149–154.

    Article  PubMed  CAS  Google Scholar 

  • Singal, D.P., Ye, M., and Bienzle, D. (1998). Transfection of TAP 1 Gene Restores HLA Class I Expression in Human Small-Cell Lung Carcinoma. Int. J. Cancer, 75, 112–116.

    Article  PubMed  CAS  Google Scholar 

  • Sprent, J., and Kishimoto, H. (2001). The Thymus and Central Tolerance. Philos. Trans. R. Soc. London B. Biol. Sci., 356, 609–616.

    Article  PubMed  CAS  Google Scholar 

  • Sprent, J., Lo, D., Gao, E.K., and Ron, Y. (1988). T Cell Selection in the Thymus. Immunol. Rev., 101, 173–190.

    Article  PubMed  CAS  Google Scholar 

  • Tay, C.H., Szornolanyi-Tsuda, E., and Welsh, R.M. (1998). Control of Infections by NK Cells. Curr Top. Microbiol. Immunol., 230, 193–220.

    Article  PubMed  CAS  Google Scholar 

  • Teisserenc, H., Schmitt, W., Blake, N., Dunbar, R., Gadola, S., Gross, W.L., et al. (1997). A Case of Primary Immunodeficiency due to a Defect of the Major Histocompatibility Gene Complex Class I Processing and Presentation Pathway. Immunol. Lett., 57, 183–187.

    Article  PubMed  CAS  Google Scholar 

  • Toes, R.E., Nussbaum, A.K., Degermann, S., Schirle, M., Emmerich, N.P., Kraft, M., et al. (2001). Discrete Cleavage Motifs of Constitutive and Immunoproteasomes Revealed by Quantitative Analysis of Cleavage Products. J. Exp. Med., 194, 1–12.

    Article  PubMed  CAS  Google Scholar 

  • Tomazin, R., Hill, A.B., Jugovic, P., York, I., van Endert, P., Ploegh, H.L., et al. (1996). Stable Binding of the Herpes Simplex Virus ICP47 Protein to the Peptide Binding Site of TAP. EMBO J., 15, 3256–3266.

    PubMed  CAS  Google Scholar 

  • Touraine, J.L., Betuel, H., Souillet, G., and Jeune, M. (1978). Combined Immunodeficiency Disease Associated with Absence of Cell-Surface HLA-A and-B Antigens. J. Pediatr., 93, 47–51.

    Article  PubMed  CAS  Google Scholar 

  • Townsend, A.R., Bastin, J., Gould, K., and Brownlee, G.G. (1986). Cytotoxic T Lymphocytes Recognize Influenza Haemagglutinin that Lacks a Signal Sequence. Nature, 324, 575–577.

    Article  PubMed  CAS  Google Scholar 

  • Townsend, A., Ohlen, C., Bastin, J., Ljunggren, H.G., Foster, L., and Karre, K. (1989). Association of Class I Major Histocompatibility Heavy and Light Chains Induced by Viral Peptides. Nature, 340, 443–448.

    Article  PubMed  CAS  Google Scholar 

  • Trowsdale, J., Ragoussis, J., and Campbell, R.D. (1991). Map of the Human MHC. Immunol. Today, 12, 443–446.

    Article  PubMed  CAS  Google Scholar 

  • Uebel, S. and Tampé, R. (1999). Specificity of the Proteasome and the TAP Transporter. Curr Opin. Immunol., 11, 203–208.

    Article  PubMed  CAS  Google Scholar 

  • Uebel, S., Kraas, W., Kienle, S., Wiesmüller, K.H., Jung, G., and Tampé, R. (1997). Recognition Principle of the TAP Transporter Disclosed by Combinatorial Peptide Libraries. Proc. Natl Acad. Sci. USA, 94, 8976–8981.

    Article  PubMed  CAS  Google Scholar 

  • Varnbutas, A., Bonagura, V.R. and Steinberg, B.M. (2000). Altered Expression of TAP-1 and Major Histocompatibility Complex Class I in Laryngeal Papillomatosis: Correlation of TAP-l with Disease. Clin. Diagn. Lab. Immunol., 7, 79–85.

    Google Scholar 

  • Vambutas, A., DeVoti, J., Pinn, W., Steinberg, B.M., and Bonagura, V.R. (2001). Interaction of Human Papillomavirus Type 11 E7 Protein with TAP-l Results in the Reduction of ATP-Dependent Peptide Transport. Clin. Immunol., 101, 94–99.

    Article  PubMed  CAS  Google Scholar 

  • van Endert, P.M. (1999). Role of Nuclcotides and Peptide Substrate for Stability and Functional Stat e of the Human ABC Family Transporters Associated with Antigen Processing. J. Biol. Chem., 274, 14632–14638.

    Article  PubMed  Google Scholar 

  • Vejbaesya, S., Luangtrakool, P., Luangtrakool, K., Sermduangprateep, C., and Parivisutt, L. (2000). Analysis of TAP and HLA-DM Polymorphism in Thai Rheumatoid Arthritis. Hum. Immunol., 61, 309–313.

    Article  PubMed  CAS  Google Scholar 

  • Vitale, M., Rezzani, R., Rodella, L., Zauli, G., Grigolato, P., Cadei, M., et al. (1998). HLA Class I Antigen and Transporter Associated with Antigen Processing (TAP 1 and TAP2) Down-Regulation in High-Grade Primary Breast Carcinoma Lesions. Cancer Res., 58, 737–742.

    PubMed  CAS  Google Scholar 

  • White, C.A., Thomson, S.A., Cooper, L., van Endert, P.M., Tarnpé, R., Coupar, B., et al. (1998). Constitutive Transduction of Peptide Transporter and HLA Genes Restores Antigen Processing Function and Cytotoxic T Cell-Mediated Immune Recognition of Human Melanoma Cells. Int. J. Cancer, 75, 590–595.

    Article  PubMed  CAS  Google Scholar 

  • Wiertz, E., Hill, A., Tortorella, D., and Ploegh, H. (1997). Cytomegaloviruses use Multiple Mechanisms to Elude the Host Immune Response. Immunol. Lett., 57, 213–216.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, C.M., Farmery, M.R., and Bulleid, N.J. (2000). Pivotal Role of Calnexin and Mannose Trimming in Regulating the Endoplasmic Reticulum-Associated Degradation of Major Histocompatibility Complex Class I Heavy Chain. J. Biol. Chem., 275, 21224–21232.

    Article  PubMed  CAS  Google Scholar 

  • Wright, K.L., White, L.C., Kelly, A., Beck, S., Trowsdale, J., and Ting, J.P. (1995). Coordinate Regulation of the Human TAP1 and LMP2 Genes from a Shared Bidirectional Promoter. J. Exp. Med., 181, 1459–1471.

    Article  PubMed  CAS  Google Scholar 

  • Yan, G., Shi, L., and Faustman, D. (1999). Novel Splicing of the Human MHC-Encoded Peptide Transporter Confers Unique Properties. J. immunol., 162, 852–859.

    PubMed  CAS  Google Scholar 

  • York, I.A. and Rock, K.L. (1996). Antigen Processing and Presentation by the Class I Major Histocompatibility Complex. Annu. Rev. Immunol., 14, 369–396.

    Article  PubMed  CAS  Google Scholar 

  • Zeidler, R., Eissner, G., Meissner, P., Uebel, S., Tarnpé, R., Lazis, S., et al. (1997). Downregulation of TAP1 in B Lymphocytes by Cellular and Epstein-Barr VirusEncoded Interleukin-10. Blood, 90, 2390–2397.

    PubMed  CAS  Google Scholar 

  • Zhang, L. and Pagano, J.S. (2001). Interferon Regulatory Factor 7 Mediates Activation of Tap-2 by Epstein—Barr Virus Latent Membrane Protein 1. J. virol., 75, 341–350.

    Article  PubMed  CAS  Google Scholar 

  • Zhu, K., Wang, J., Zhu, J., Jiang, J., Shou, J., and Chen, X. (1999). p53 Induces TAP1 and Enhances the Transport of MHC Class I Peptides. Oncogene, 18, 7740–7747.

    Article  PubMed  CAS  Google Scholar 

  • Zimmer, J., Donato, L., Hanau, D., Cazenave, J.P., Tongio, M.M., Moretta, A., et al. (1998). Activity and Phenotype of Natural Killer Cells in Peptide Transporter (TAP)-Deficient Patients (Type I Bare Lymphocyte Syndrome). J. Exp. Med., 187, 117–122.

    Article  PubMed  CAS  Google Scholar 

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  1. Institute of Biochemistry Biocenter Frankfurt, Goethe-University, Frankfurt Marie-Curie-Strasse 9, D-60439, Frankfurt, Germany

    Silke Beismann-Driemeyer, Silke Beismann-Driemeyer & Robert Tampé

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  1. Silke Beismann-Driemeyer
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  1. Australian National University, Canberra, Australia

    Stefan Bröer

  2. University of Zurich, Zurich, Switzerland

    Carsten A. Wagner

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Beismann-Driemeyer, S., Tampé, R. (2003). Function of the transporter associated with antigen processing (TAP) in cellular immunity, tumor escape, and virus persistence. In: Bröer, S., Wagner, C.A. (eds) Membrane Transporter Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9023-5_21

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  • DOI: https://doi.org/10.1007/978-1-4419-9023-5_21

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