Mathematical Modeling in Nutrition and the Health Sciences

Volume 537 of the series Advances in Experimental Medicine and Biology pp 1-19

The Minimal Model of Glucose Regulation: A Biography

  • Richard N. BergmanAffiliated withDepartment of Physiology and Biophysics and USC Diabetes Research Center, University of Southern CaliforniaDepartment of Physiology and Biophysics, Keck-USC School of Medicine

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The life history of the so-called “minimal model” of glucose regulation can be traced back over two decades. During the decades after World War II, the science of cybernet-ics was introduced by Norbert Weiner at MIT (Weiner,1965). Weiner recognized the importance of the rapidly developing fields of control theory and systems analysis to problems in biology and medicine. During the ensuing decade, much was written about the potential benefits of applying mathematical analysis to biology (Yates et al., 1972).