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Immunobiology of Organ Transplantation pp 509–523Cite as

Heme Oxygenase-1 and Transplantation

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Abstract

The discovery of nitric oxide (NO) in 1987 unraveled the novel concept that an endogenous production of a gaseous substance such as NO can impart diverse and critical functional effects on a wide spectrum of biological and pathological processes. These investigations have led to numerous fruitful discoveries, enhancing our understanding of many disease processes including lung disorders. Interestingly though, we have known for a longer period of time that there exists another gaseous molecule, carbon monoxide (CO), which can be generated endogenously; that is, the heme oxygenase (HO) enzyme system generates the majority, if not, all of the endogenous CO’. Since the isolation of the HO enzyme in 1968, the major focus of HO research was in the study of HO in heme metabolism based on the known fact that the HO enzyme serves as the rate-limiting enzyme in the degradation of heme. However, in recent years, due to the emerging role of HO in a variety of biological processes, interest in HO has continued to grow beyond its role in heme metabolism and expanded into many scientific disciplines. The recent discovery of the HO enzyme system not only in yeast, but also in the prokaryotic bacterial system and in plants further highlights the functional importance of a highly conserved enzyme throughout the evolution of living organisms’.

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Authors and Affiliations

  1. Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT, USA

    Patty J. Lee

  2. University of Pittsburgh, Pittsburgh, PA, USA

    Ruiping Song & Augustine M. K. Choi

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  1. Patty J. Lee
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  2. Ruiping Song
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  3. Augustine M. K. Choi
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Editors and Affiliations

  1. Microbiology and Immunobiology, Division of Pulmonary and Critical Care Medicine, Indiana University School of Medicine, Indianapolis, Indiana

    David S. Wilkes M.D. (Calvin H. English Professor of Medicine) (Calvin H. English Professor of Medicine)

  2. Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, Wisconsin

    William J. Burlingham Ph.D. (Associate Professor) (Associate Professor)

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Lee, P.J., Song, R., Choi, A.M.K. (2004). Heme Oxygenase-1 and Transplantation. In: Wilkes, D.S., Burlingham, W.J. (eds) Immunobiology of Organ Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8999-4_28

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  • DOI: https://doi.org/10.1007/978-1-4419-8999-4_28

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