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Interaction of Innate and Acquired Immune Response: Toll Receptors— Potential Link of Infection to Rejection

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Immunobiology of Organ Transplantation

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Abstract

Infection by microbial organisms results in an activation of the immune system. The toll-like receptor (TLR) performs a decisive role in the initiation of innate immune responses by recognizing the pathogen-associated molecular pattern (PAMP) and delivering the signals that are critical for the generation of adaptive immune responses. The success of organ transplantation relies on a complete blockage of immune responses. Since T cells are considered major effector cells during organ transplantation, many studies on transplantation immunology have been focused on adaptive immune responses. However, activation of T cells requires signals generated by innate immune responses. Therefore, a thorough understanding of innate immune responses is critical. Moreover, it has been reported recently that CD4+ T helper cells can be activated by the result of innate immune responses in the absence of an MHC class II antigen’.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Indiana University School of Medicine, Walther Oncology Center, Indianapolis, IN, USA

    Soon-Cheol Hong

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  1. Microbiology and Immunobiology, Division of Pulmonary and Critical Care Medicine, Indiana University School of Medicine, Indianapolis, Indiana

    David S. Wilkes M.D. (Calvin H. English Professor of Medicine) (Calvin H. English Professor of Medicine)

  2. Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, Wisconsin

    William J. Burlingham Ph.D. (Associate Professor) (Associate Professor)

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Hong, SC. (2004). Interaction of Innate and Acquired Immune Response: Toll Receptors— Potential Link of Infection to Rejection. In: Wilkes, D.S., Burlingham, W.J. (eds) Immunobiology of Organ Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8999-4_25

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  • DOI: https://doi.org/10.1007/978-1-4419-8999-4_25

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