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Masculinization of Female Mammals: Lessons from Nature

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Hypospadias and Genital Development

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 545))

Abstract

Conventional understanding of mammalian sexual differentiation, first proposed by Alfred Jost in the late 1940’s and early 1950’s, requires the presence of androgens acting during a critical stage of fetal (or neonatal) life for normal development of the masculine penis and scrotum from embryonic primordia (Jost, 1953; Wilson et al., 1981). Postnatally, a marked acceleration in growth of the penis is typically associated with increased secretion of androgen during puberty (at least in primates).

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Place, N.J., Glickman, S.E. (2004). Masculinization of Female Mammals: Lessons from Nature. In: Baskin, L.S. (eds) Hypospadias and Genital Development. Advances in Experimental Medicine and Biology, vol 545. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8995-6_15

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  • DOI: https://doi.org/10.1007/978-1-4419-8995-6_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4752-1

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