Malaria

  • Kathryn Maitland
  • Malcolm Molyneux
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 549)

Abstract

Globally, malaria is the most important parasite infection in terms of the geographic distribution and its effect on health and economic growth. Over a third of the world’s population live in malaria-endemic areas (Guerin et al., 2002), however the greatest burden on public health is in sub-Saharan Africa, where at least 90% of malarial infections and deaths in the world occur (Teklehaimanot and Snow, 2002), the latter almost entirely in children less than 5 years old. Each year, malaria results in an estimated 200–450 million cases of fever in children and over 0.5 million deaths (Snow et al., 1999). The burden of malaria is increasing, especially in sub-Saharan Africa, and this increase is mainly attributable to drug and insecticide resistance and social and environmental changes (Greenwood and Mutabingwa, 2002).

Keywords

Anemia Retina Dexamethasone Neurol Malaria 

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References

  1. American Heart Association. (1997). Pediatric Advanced Life Support 1997-1999: Emergency Cardiovascular Care Programs.Google Scholar
  2. Berkley, J., Mwarumba, S., Bramham, K., Lowe, B., and Marsh, K. (1999). Bacteraemia complicating severe malaria in children. Trans. R. Soc. Trop. Med. Hyg. 93, 283–286.PubMedCrossRefGoogle Scholar
  3. BMJ Publishing Group. (1993). Advanced paediatric life support: The practical approach. London.Google Scholar
  4. Bondi, F.S. (1992). The incidence and outcome of neurological abnormalities in childhood cerebral malaria: A long-term follow-up of 62 survivors. Trans. R. Soc. Trop. Med. Hyg. 86, 17–19.PubMedCrossRefGoogle Scholar
  5. Brown, H., Hien, T.T., Day, N., Mai, N.T., Chuong, L.V., Chau, T.T. Loc, P.P., Phu, N.H., Bethell, D., Farrar, J., Gatter, K., White, N., and Turner, G. (1999). Evidence of blood-brain barrier dysfunction in human cerebral malaria. Neuropathol. Appl. Neuwbiol. 25, 331–340.CrossRefGoogle Scholar
  6. Brown, H., Rogerson, S., Taylor, T., Tembo, M., Mwenechanya, J., Molyneux, M., and Turner, G. (2001). Blood-brain barrier function in cerebral malaria in Malawian children. Am. J. Trop. Med. Hyg. 64, 207–213.PubMedGoogle Scholar
  7. Brown, H.T., Rogerson, G., Tembo, S.J., Mwenechanya, M., Dzinjalamala, J.F., Molyneux, M.E., Taylor, T.E. (1999). Cytokine expression in the brain in human cerebral malaria. J. Infect. Dis. 180, 1742–1746.PubMedCrossRefGoogle Scholar
  8. Chang, T.M. (2000). Red blood cell substitutes. Baillieres Best Pract. Res. Clin. Haematol. 13, 651–667.PubMedCrossRefGoogle Scholar
  9. Chen, Q., Schlichtherle, M., and Wahlgren, M. (2000). Molecular aspects of severe malaria. Clin. Microbiol. Rev. 13, 439–450.PubMedCrossRefGoogle Scholar
  10. Crawley, J., English, M., Waruiru, C., Mwangi, I., and Marsh, K. (1998). Abnormal respiratory patterns in childhood cerebral malaria. Trans. R. Soc. Trop. Med. Hyg. 92, 305–308.PubMedCrossRefGoogle Scholar
  11. Crawley, J., Smith, S., Kirkham, F., Muthinji, P., Waruiru, C., and Marsh, K. (1996). Seizures and status epilepticus in childhood cerebral malaria. QJM 89, 591–597.PubMedCrossRefGoogle Scholar
  12. Dondorp, A.M., Kager, P.A., Vreeken, J., and White, N.J. (2000). Abnormal blood flow and red blood cell deformability in severe malaria. Parasitol. Today 16, 228–232.PubMedCrossRefGoogle Scholar
  13. Dondorp, A.M., Nyanoti, M., Kager, P. A., Mithwani, S., Vreeken, J., and Marsh, K. (2002). The role of reduced red cell deformability in the pathogenesis of severe falciparum malaria and its restoration by blood transfusion. Trans. R. Soc. Trop. Med. Hyg. 96, 282–286.PubMedCrossRefGoogle Scholar
  14. English, M. (2000). Life-threatening severe malarial anaemia. Trans. R. Soc. Trop. Med. Hyg. 94, 585–588.PubMedCrossRefGoogle Scholar
  15. English, M., Ahmed, M., Ngando, C., Berkley, J., and Ross, A. (2002). Blood transfusion for severe anaemia in children in a Kenyan hospital. Lancet 359, 494–495.PubMedCrossRefGoogle Scholar
  16. English, M., Muambi, B., Mithwani, S., and Marsh, K. (1997). Lactic acidosis and oxygen debt in African children with severe anaemia. QJM 90, 563–569.PubMedCrossRefGoogle Scholar
  17. English, M., Murphy, S., Mwangi, I., Crawley, J., Peshu, N., and Marsh, K. (1995). Interobserver variation in respiratory signs of severe malaria. Arch. Dis. Child 72, 334–336.PubMedCrossRefGoogle Scholar
  18. English, M., Waruiru, C., Amukoye, E., Murphy, S., Crawley, J., Mwangi, I. et a!. (1996a). Deep breathing in children with severe malaria: Indicator of metabolic acidosis and poor outcome. Am. J. Trop. Med. Hyg. 55, 521–524.PubMedGoogle Scholar
  19. English, M., Waruiru, C., and Marsh, K. (1996b). Transfusion for respiratory distress in life-threatening childhood malaria. Am. J. Trop. Med. Hyg. 55, 525–530.PubMedGoogle Scholar
  20. Greenwood, B. and Mutabingwa, T. (2002). Malaria in 2002. Nature 415, 670–672.PubMedCrossRefGoogle Scholar
  21. Guerin, P.J., Olliaro, P., Nosten, F., Druilhe, P., Laxminarayan, R., Binka, F. et al. (2002). Malaria: Current status of control, diagnosis, treatment, and a proposed agenda for research and development. Lancet Infect. Dis. 2, 564–573.PubMedCrossRefGoogle Scholar
  22. Hall, A.P. (1976). The treatment of malaria. Br. Med. J. 1, 323–328.PubMedCrossRefGoogle Scholar
  23. Krishna, S., Agbenyega, T., Angus, B.J., Bedu-Addo, G., Ofori-Amanfo, G., Henderson, G. et al. (1995). Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria. QJM 88, 341–349.PubMedGoogle Scholar
  24. Krishna, S., Waller, D.W., ter Kuile, F., Kwiatkowski, D., Crawley, J., Craddock, C.F. et al. (1994). Lactic acidosis and hypoglycaemia in children with severe malaria: Pathophysiological and prognostic significance. Trans. R. Soc. Trop. Med. Hyg. 88, 67–73.PubMedCrossRefGoogle Scholar
  25. Kublin, J., Cortese, J., Njunju, E., Mukadam, R., Wirima, J., Kazembe, P. et al. (2003). Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. Lancet Infect. Dis. 187, 1870–1875.Google Scholar
  26. Kyes, S., Horrocks, P., and Newbold, C. (2001). Antigenic variation at the infected red cell surface in malaria. Annu. Rev. Microbiol. 55, 673–707.PubMedCrossRefGoogle Scholar
  27. Lackritz, E.M., Hightower, A.W., Zucker, J.R., Ruebush, T.K., 2nd, Onudi, C.O., Steketee, R.W. et al. (1997). Longitudinal evaluation of severely anemic children in Kenya: The effect of transfusion on mortality and hematologic recovery. AIDS 11, 1487–1494.PubMedCrossRefGoogle Scholar
  28. Lewallen, S., Harding, S.P., Ajewole, J., Schulenburg, W.E., Molyneux, M.E., Marsh, K., Usen, S., White, N.J., and Taylor, T.E. (1999). A review of the spectrum of clinical fundus findings in P. falciparum malaria in African children with a proposed classification and grading system. Trans. Roy. Soc. Trop. Med. Hyg. 93, 619–622.PubMedCrossRefGoogle Scholar
  29. Lewallen, S., White, V.A., Whitten, R.O., Gardiner, J., Hoar, B., Lindley, J., Lochhead, J., McCormick, A., Wade, K., Tembo, M., Mwenechanyana, J., Molyneux, M.E., and Taylor, T.E. (2000). Clinical-histopathological correlation of the abnormal retinal vessels in cerebral malaria. Arch. Ophthalmol. 118, 924–928.PubMedGoogle Scholar
  30. Maitland, K., Levin, M., English, M., Peshu, N., Mithwani, S., Marsh, K., and Newton, C. (2003a). Severe P. falciparum malaria in Kenyan children: Evidence for hypovolaemia. Q. J. Med. 96, 427–434.CrossRefGoogle Scholar
  31. Maitland, K., Pamba, A., Newton, C.R., and Levin, M. (2003b). Response to volume resuscitation in children with severe malaria. Pediatr. Crit. Care. Med. 4, 426–431.PubMedCrossRefGoogle Scholar
  32. Marsh, K., Forster, D., Waruiru, C., Mwangi, I., Winstanley, M., Marsh, V. (1995). Indicators of life-threatening malaria in African children. N. Engl. J. Med. 332, 1399–1404.PubMedCrossRefGoogle Scholar
  33. Molyneux, M.E., Taylor, T.E., Wirima, J.J., and Borgstein, A. (1989). Clinical features and prognostic indicators in paediatric cerebral malaria: A study of 131 comatose Malawian children. Q. J. Med. 71, 441–459.PubMedGoogle Scholar
  34. Newton, C.R., Crawley, J., Sowumni, A., Waruiru, C., Mwangi, I., English, M. et al. (1997). Intracranial hypertension in Africans with cerebral malaria. Arch. Dis. Child. 76, 219–226.PubMedCrossRefGoogle Scholar
  35. Newton, C.R., Hien, T.T., and White, N. (2000). Cerebral malaria. J. Neurol. Neurosurg. Psychiatry. 69, 433–441.PubMedCrossRefGoogle Scholar
  36. Newton, C.R. and Krishna, S. (1998). Severe falciparum malaria in children: Current understanding of pathophysiology and supportive treatment. Pharmacol. Ther. 79, 1–53.PubMedCrossRefGoogle Scholar
  37. Newton, C.R., Marsh, K., Peshu, N., and Kirkham, F.J. (1996). Perturbations of cerebral hemodynamics in Kenyans with cerebral malaria. Pediatr. Neurol. 15, 41–49.PubMedCrossRefGoogle Scholar
  38. Newton, C.R., Peshu, N., Kendall, B., Kirkham, F.J., Sowunmi, A., Waruiru, C. et al. (1994). Brain swelling and ischaemia in Kenyans with cerebral malaria. Arch. Dis. Child 70, 281–287.PubMedCrossRefGoogle Scholar
  39. Snow, R.W.C., Deichmann, M.H., U. et al. (1999). A preliminary continental risk map for malaria mortality among African children. Parasitol. Today 15, 99–104.PubMedCrossRefGoogle Scholar
  40. Taylor, T.E., Borgstein, A., and Molyneux, M.E. (1993). Acid-base status in paediatric Plasmodium falciparum malaria. Q. J. Med. 86, 99–109.PubMedGoogle Scholar
  41. Teklehaimanot, A. and Snow, R.W. (2002). Will the Global Fund help roll back malaria in Africa? Lancet 360, 888–889.PubMedCrossRefGoogle Scholar
  42. Walker, O., Salako, L.A., Sowunmi, A., Thomas, J.O., Sodeine, O., and Bondi, F.S. (1992). Prognostic risk factors and post mortem findings in cerebral malaria in children. Trans. R. Soc. Trop. Med. Hyg. 86, 491–493.PubMedCrossRefGoogle Scholar
  43. Watt, G., Jongsakul, K., and Ruangvirayuth, R. (2002). A pilot study of N-acetylcysteine as adjunctive therapy for severe malaria. QJM 95, 285–290.PubMedCrossRefGoogle Scholar
  44. White, N.J. (1998). Not much progress in treatment of cerebral malaria. Lancet 352, 594–595.PubMedCrossRefGoogle Scholar
  45. White, V.A., Lewallen, S., Beare, N., Kayira, K., Carr, R.A., and Taylor, T. E. (2001). Correlation of retinal haemorrhages with brain haemorrhages in children dying of cerebral malaria in Malawi. Trans. R. Soc. Trop. Med. Hyg. 95, 618–621.PubMedCrossRefGoogle Scholar
  46. World Health Organization. (1990). Severe and complicated malaria. Division of Control of Tropical Diseases. Trans. R. Soc. Trop. Med. Hyg. 84, 1–65.CrossRefGoogle Scholar
  47. World Health Organization. (2000). Severe falciparum malaria. Communicable Diseases Cluster. Trans. R. Soc. Trop. Med. Hyg. 94 (Suppl 1), S1–S90.CrossRefGoogle Scholar

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© Science+Business Media New York 2004

Authors and Affiliations

  • Kathryn Maitland
  • Malcolm Molyneux

There are no affiliations available

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