The Relation of Repeats to Position Effect in Drosophila Melanogaster

  • E. B. Lewis


In Drosophila melanogaster it has been established that the action of at least some genes is affected by their position in the chromosomes. Critical evidence for this phenomenon of position effect has been given by Sturtevant (1925), Dubinin and Sidorow (1935), and Panshin (1935). Position effects have been detected only in cases in which the relative position of a gene with respect to its neighbors has been altered by a chromosomal rearrangement. It is conceivable that the effective position of a gene may also be changed as a result of a substitution in an adjacent gene of one allele by another. Such a possibility was put to experimental test by Sturtevant (1928) for the dominant mutants, Delta (Dl) and Hairless (H), three units apart in the third chromosome; however, no difference could be demonstrated between Dl H/++ and Dl+/+H.


Land Chromosome Osition Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. Bridges C. B., 1935. Salivary chromosome maps. J. Hered. 26: 60–64.Google Scholar
  2. Bridges C. B., 1936. The Bar “gene” a duplication. Science 83: 210–211.PubMedCrossRefGoogle Scholar
  3. Bridges C. B., and K. S. Brehme, 1944. The mutants of Drosophila melanogaster. Carnegie Instn.Washington, Publ. 552, 257 pp.Google Scholar
  4. Bridges C. B., and J. C. Li, 1936. Investigations on the constitution of the germinal material in relation to heredity. Yearb. Carnegie Instn. 35: 292.Google Scholar
  5. Bridges C. B., and T. H. Morgan, 1919. Contributions to the genetics of Drosophila melanogaster. Carnegie Instn. Washington Publ. 278: 123–304.Google Scholar
  6. Bridges C.B., E.N. Skoog, and J.C. Li, 1936. Genetical and cytological studies of a deficiency (Notopleural) in the second chromosome of Drosophila melanogaster. Genetics 21: 788–795.PubMedGoogle Scholar
  7. Bridges P. N., 1942. A new map of the salivary gland chromosome. J. Hered. 33: 403–408.Google Scholar
  8. Demerec M., 1928. Mutable characters of Drosophila virilis. I. Reddish-alpha body character Genetics 13: 359–388.Google Scholar
  9. Dubinin N. P., and B.N. Sidorov, 1935. The position effect of the hairy gene. Biol. Zh. (Mosc.) 4: 555–568.Google Scholar
  10. Griffen A. B., 1941. The B s translocation in Drosophila melanogaster and modifications of the Bar effect through irradiation. (Abstract.) Genetics 26: 154.Google Scholar
  11. Lewis E. B., 1941. Another case of unequal crossing over in Drosophila melanogaster. Proc. Nat. Acad. Sci. 27: 31–34.PubMedCrossRefGoogle Scholar
  12. Metz C.W., 1937. Small deficiencies and the problem of genetic units in the giant chromosomes. Genetics 22: 543–PubMedGoogle Scholar
  13. Metz C.W., 1938 Observations on evolutionary changes in the chromosomes of Sciara (Diptera). Carnegie Instn. Washington Publ. 501: 275–Google Scholar
  14. Muller H. J., 1936. Bar duplication. Science 83: 528–530.PubMedCrossRefGoogle Scholar
  15. Muller H. J.,1941 Induced mutations in Drosophila. Cold Spring Harbor Symp. Quant. Biol. 9: 151–165.CrossRefGoogle Scholar
  16. Muller H. J., and T. S. Painter, 1929. The cytological expression of changes in gene alignment produced by X-rays in Drosophila. Amer. Nat. 63: 193–200.CrossRefGoogle Scholar
  17. Muller H. J., A. A. Prokofyeva-Belgovskaya, and K. V. Kossikov, 1936. Unequal crossing-over in the Bar mutant as a result of duplication of a minute chromosome section. C. R. Acad. Sci. U.S.S.R. 1: 87–88.Google Scholar
  18. Oliver C. P., 1940. A reversion to wild type associated with crossing over in Drosophila melanogaster. Proc. Nat. Acad. Sci. 26: 452–454.PubMedCrossRefGoogle Scholar
  19. Panshin I. B., 1935. New evidence for the position effect hypothesis. C. R. Acad. Sci. U.S.S.R. 4: 70–71.Google Scholar
  20. Stern C., and C. B. Bridges, 1926. The mutants at the extreme left end of the second chromosome of Drosophila melanogaster. Genetics 11: 503–530.PubMedGoogle Scholar
  21. Sturtevant A. H., 1925. The effects of unequal crossing over at the Bar locus in Drosophila. Genetics 10: 117–147.PubMedGoogle Scholar
  22. Sturtevant A. H., 1928 A further study of the so-called mutation at the Bar locus of Drosophila. Genetics 13: 401–409.PubMedGoogle Scholar
  23. Sutton E., 1943. Bar eye in Drosophila melanogaster; A cytological analysis of some mutations and reverse mutations. Genetics 28: 97–107.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • E. B. Lewis
    • 1
  1. 1.Wm. G. Kerckhoff LaboratoriesCalifornia Institute of TechnologyPasadenaUSA

Personalised recommendations