Abstract
The way in which genes control the growth and development of an organism is a central problem in biology, and one which is currently under study in diverse forms from phage to man. I would like to discuss an approach to this problem which makes use of a series of pseudoallelic genes in Drosophila. Such series of closely linked genes with related effects have, in several instances, been profitably exploited in the bacteria to learn more about how genes control biochemical pathways. Striking examples are the linked genes controlling histidine biosynthesis in Salmonella (Demerec and Hartman, 1959; Ames and Hartman, 1962), or lactose utilization in E. coli (Jacob and Monod, 1961a,b). It may be anticipated that pseudoallelic series affecting morphological traits, such as the case to be described below, can also be profitably exploited to learn more about how genes control developmental pathways.
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References
Ames B. N., and P. E. Hartman. 1962. Genes, enzymes and control mechanisms in histidine biosynthesis. p. 322–334. In Molecular basis of neoplasia. Univ. of Texas Press Austin, Texas.
Benzer S. 1955. Fine structure of a genetic region in bacteriophage. Proc. Natl. Acad. Sci. 41:344–354.
Benzer S. 1957. The elementary units of heredity. p. 70–93. In W. D. McElroy and B. Glass (eds.), The chemical basis of heredity. The Johns Hopkins Press Baltimore, Md.
Brown S.W., and A. Hannah. 1952. An induced maternal effect on the stability of the ring-X chromosome of Drosophila melanogaster. Proc. Natl. Acad. Sci. 38:687–693.
Carlson E. A. 1959. Comparative genetics of complex loci. Quart. Rev. Biol. 34: 33–67.
Case M. E., and N. H. Giles. 1958. Recombination mechanisms at the pan-2 locus in Neurospora crassa. Cold Spr. Harb. Symp. Quant. Biol. 23: 119–135.
Catcheside D. G., and A. Overton. 1958. Complementation between alleles in heterocaryons. Cold Spr. Harb. Symp. Quant. Biol, 23:137–140.
Chovnick A., A Schalet, R. P. Kernaghan, and J. Talsma. 1962. The resolving power of genetic fine structure analysis in higher organisms as exemplified by Drosophila. Amer. Nat. 96: 281–296.
Demerec M., and P. E. Hartman. 1959. Complex loci in micro-organisms. Ann. Rev. Microbiol. 13:377–406.
Dunn L. C. 1954. The study of complex loci. Proc. 9 Intern. Congr. Genetics, Bellagio, Italy, 1953. Caryologia 6:155–166.
Gloor H. 1947. Phanokopie-versuche mit Äther an Drosophila. Rev. Suisse Zool. 54: 637–712.
Hannah A. 1953. Non-autonomy of yellow in gynandromorphs of Drosophila melanogster. J. Exptl. Zool. 123: 523–560.
Henning U., and C. Yanofsky. 1962. Amino acid replacements associated with reversion and recombination within the A-gene. Proc. Natl. Acad. Sci. 48:1497–1504.
Ingram V. M. 1961. Gene evolution and the haemoglobins. Nature 189:704–708.
Itikawa N. 1952. Genetical and embryological studies on the E-multiple alleles in the silkworm, Bombyx mori. L. Bull. Sericultural Exptl. Station (Tokyo) 14: 23–91.
Itikawa N. 1955. An example of the silkwormmothwhich has the 3rd wing incompletely developed. [in Japanese]. Acta Sericologia 12:13–15.
Jacob F., D. Perrin, C. Sanchez, and J. Monod. 1960. L’opéron: groupe de gènes à expression coordonnée par un opérateur. C.R. Acad. Sci. 250:1727–1729.
Jacob F., and J. Monod. 1961a. Genetic regulatory mechanisms in the synthesis of proteins. J. Mol. Biol. 3:318–356.
Jacob F., and J. Monod. 1961b. On the regulation of gene activity. Cold Spr. Harb. Symp. Quant. Biol. 26:193–211.
Lewis E. B. 1951. Pseudoallelism and gene evolution. Cold Spr. Harb. Symp. Quant. Biol. 16:159–174.
Lewis E. B. 1954a. The theory and application of a new method of detecting chromosomal rearrangements in Drosophila melanogaster. Amer. Nat. 88:225–239.
Lewis E. B. 1954b. Pseudoallelism and the gene concept. Proc. 9 Intern. Congr. Genetics, Bellagio, Italy, 1953. Caryologia 6:100–105.
Lewis E. B. 1955. Some aspects of position pseudoallelism. Amer. Nat. 89:73–89.
Lewis E. B. 1957. Two wings or four? Engineering and Science Monthly 21:19–21.
Mitchell M. B. 1955. Aberrant recombination in Neurospora. Proc. Natl. Acad. Sci. 41: 935–937.
Nelson O. E. 1962. The waxy locus in maize. I. Intralocus recombination frequency estimates by pollen and by conventional analyses. Genetics 47:737–742.
Pontecorvo G. 1958. Trends in genetic analysis. Columbia University Press New York.
Pritchard R. H. 1955. The linear arrangement of a series of alleles of Aspergillus nidulans. Heredity 9:343–371.
Pritchard R. H. 1960. The bearing of recombination analysis at high resolution on genetic fine structure in Aspergillus nidulans and the mechanism of recombination in higher organisms. Symp. Soc. Gen. Microbiol. 10:155–180.
Roman H. 1956. Studies of gene mutation in Saccharomyces. Cold Spr. Harb. Symp. Quant. Biol. 21: 175–185.
Tsujita M. 1955. On the crossing-over between EH and EK of the E allelic series in the silkworm. Jap. J., Genetics 30:227–235.
Welshons W. J., and E. S. Von Halle. 1962. Pseudoallelism at the Notch locus in Drosophila. Genetics 47:743–759.
Zalokar M. 1947. Anatomie du thorax de Drosophila melanogaster. Rev. Suisse Zool. 54:17–53.
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Lewis, E.B. (2004). Genes and Developmental Pathways. In: Lipshitz, H.D. (eds) Genes, Development and Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8981-9_12
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DOI: https://doi.org/10.1007/978-1-4419-8981-9_12
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