Peri-Follicular Vascularity: A Marker of Follicular Heterogeneity and Oocyte Competence and a Predictor of Implantation in Assisted Conception Cycles
Angiogenesis, the development of new blood vessels, has been described as a foeto-oncogenic event, being a feature of foetal development and associated with the development of tumours. Controlled, cyclical angiogenesis is however, uniquely expressed in the adult female reproductive tract. Angiogenesis in the female tract is expressed in the ovary and endometrium. In the ovary peri-follicular angiogenesis develops with the progression of the follicle to the antral stage, it continues after ovulation with the development of the corpus luteum (CL) and, in the absence of pregnancy, ceases with the regression of the corpus luteum. The cessation of angiogenic events at one site on the ovary, however, is followed by the initiation of angiogenic events at another site in conjunction with the development of new follicles. Angiogenesis in the endometrium follows implantation of the embryo. Here too it is a programd event leading to the development of the placenta but regressing in the event of early pregnancy failure.
KeywordsVascular Endothelial Growth Factor Granulosa Cell Corpus Luteum Follicular Fluid Cumulus Cell
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