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Peri-Follicular Vascularity: A Marker of Follicular Heterogeneity and Oocyte Competence and a Predictor of Implantation in Assisted Conception Cycles

  • Linda Gregory
Chapter

Abstract

Angiogenesis, the development of new blood vessels, has been described as a foeto-oncogenic event, being a feature of foetal development and associated with the development of tumours. Controlled, cyclical angiogenesis is however, uniquely expressed in the adult female reproductive tract. Angiogenesis in the female tract is expressed in the ovary and endometrium. In the ovary peri-follicular angiogenesis develops with the progression of the follicle to the antral stage, it continues after ovulation with the development of the corpus luteum (CL) and, in the absence of pregnancy, ceases with the regression of the corpus luteum. The cessation of angiogenic events at one site on the ovary, however, is followed by the initiation of angiogenic events at another site in conjunction with the development of new follicles. Angiogenesis in the endometrium follows implantation of the embryo. Here too it is a programd event leading to the development of the placenta but regressing in the event of early pregnancy failure.

Keywords

Vascular Endothelial Growth Factor Granulosa Cell Corpus Luteum Follicular Fluid Cumulus Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anthony, F., Watson, H., Richardson, M. et al. (1994). Reverse transcription and competitive CR shows increased expression of vascular endothelial growth factor (VEGF) after hCG Stimulation of cultured human granulosa cells. J. Reprod. Fertil. 13: 26–32.Google Scholar
  2. Asem, E. (2000). Effect of basal lamina on progesterone production by chicken granulosa cells in vitro — influence on follicular development. Comp Biol and Physiol, C. Comp Pharmacol and Toxicol l25:233–244.Google Scholar
  3. Antczak, M., Van Blerkom, J.and Clark. A.(1997). A novel mechanism of vascular endothelial growth factor, leptin and transforming growth factor beta-2 sequestration in a sub-population of human ovarian follicle cells. Hum. Reprod. 21: 2226–2234.CrossRefGoogle Scholar
  4. Antczak, M. and Van Blerkom, J. (2000). The vascular character of ovarian follicular granulosa cells: phenotypic and functional evidence for endothelial-like cell population. Hum. Reprod.15: 2306–2318.PubMedCrossRefGoogle Scholar
  5. Bhal, P, Pugh, N, Chui, D., Gregory, et al. (1999a). The use of transvaginal power Doppler ultrasonography to evaluate the relationship between perifollicular vascularity and outcome in in-vitro Fertilization treatment cycles. Hum. Reprod. 14: 939–945PubMedCrossRefGoogle Scholar
  6. Bhal, P., Pugh, N., Gregory, L., et al. (1999b). Perifollicular vascularity as a potential variable affecting outcome in stimulated intrauterine insemination treatment cycles, a study using transvaginal power Doppler. Hum. Reprod. 16: 1682–1689.CrossRefGoogle Scholar
  7. Biggers, J. (2002). Thoughts on embryo culture conditions. Reproductive Biom. Rev. 4(Suppl 1):30–38.CrossRefGoogle Scholar
  8. Borini, A., Maccolini, A., Tallarini, A., et al. (2001). Perifollicular vascularity and its relationship with oocyte maturity and 1VF outcome. Ann. N.Y.Acad, Sci. 943: 64–67.CrossRefGoogle Scholar
  9. Bouloumie, A., Drexler, H, Lafontan, M., and Busse, R. (1998). Leptin, the product of ob gene, promotes angiogenesis. Circulation Res. 83: 1059–1066.PubMedCrossRefGoogle Scholar
  10. Chui, D., Pugh, N., Walker, S., et al. (1997). Follicular vascularity-the predictive value of transvaginal power Doppler ultrasonography in an in vitro fertilization program. A preliminary study. Hum Reprod. 12: 191–196.PubMedCrossRefGoogle Scholar
  11. Coates, A., Rutherford, A., Hunter H. and Leese, H. (1999). Glucose-free medium in human in vitro fertilization and embryo transfer: a large scale, prospective, randomised clinical trial. Fertil. Steril 72: 229–232.PubMedCrossRefGoogle Scholar
  12. Conaghan, J., Hardy, K., Leese, H., et al. (1998). Culture of human preimplantation embryos to the blastocyst stage: a comparison of 3 media Int. J. Develop. Biol. 42(7 Spec No):885–893.Google Scholar
  13. Delhanty, J. and Handyside, A. (1995). The origin of genetic defects in the human and the detection in the preimplantation embryo. Hum. Reprod. Update 1:210–215.CrossRefGoogle Scholar
  14. Engmann, L., Sladkevicius, P., Agrawal, R., et al. (1999). The pattern of changes in ovarian stromal and uterine artery blood flow velocities during in vitro fertilization treatment and its relationship with outcome of the cycle. Ultrasound in Obstet. Gynaecol. 13: 26–33.CrossRefGoogle Scholar
  15. Erbach, G., Lawins, J., Papaioumann V. and Biggers, J. (1994). Differential growth of the mouse preimplantation embryo in chemically defined media. Biol. Reprod. 50: 1027–1033.PubMedCrossRefGoogle Scholar
  16. Ferrara, A., Chen, H., Davis-Smyth, T., et al., (1998). Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nature Medicine 4: 336–340.PubMedCrossRefGoogle Scholar
  17. Gardner D. and Lane, M. (1998) Culture of viable human blastocysts in defined sequential serum free medium. Hum. Reprod. 13(Suppl 3): 148–159.PubMedCrossRefGoogle Scholar
  18. Gardner, D.K., Lane, M., Stevens, J. and Schoolcraft, W.B. (2001). Non-invasive assessment of human embryo nutrient consumption as a measure of developmental potential. Fertil. Steril 76: 1175–1180.PubMedCrossRefGoogle Scholar
  19. Gardner, D. Pool, T. and Lane, M. (2000). Embryo nutrition and energy metabolism and its relationship to embryo growth, differentiation and viability. Sem. in Reprod. Med. 18:205–218.CrossRefGoogle Scholar
  20. Gardner D., Vella, P., Lane M., et al. (1998). Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers. Fertil. Steril 69: 94–88.CrossRefGoogle Scholar
  21. Gardner, D Lane M., Calderon, I and Leeton, J. (1996). Environment of the preimplantation human embryo in vivo: metabolic analysis of oviduct and uterine fluids and metabolism of cumulus cells. Fertil.Steril 65:349–353.PubMedGoogle Scholar
  22. Gaulden, M. (1992). The enigma of Down syndrome and other trisomic conditions. Mutation Research.269: 69–88.CrossRefGoogle Scholar
  23. Gregory, L., Booth, A., Wells, C. and Walker, S. (1994). A study of the cumulus-corona cell complex in in-vitro fertilization an embryo transfer: a prognostic indicator of the failure of implantation. Hum. Reprod. 9: 1308–1317.PubMedGoogle Scholar
  24. Gregory, L., Griffiths, A., Davies, D., et al (2001). Vascular endothelial growth factor (VEGF) production by human cumulus cells in vitro; is there a potential to contribute to angiogenic events in the endometrium in the peri-implantation period. Abstract Proceedings of the 3rd Alpha Biennial Congress, New York September 9-11. 2001Google Scholar
  25. Gregory, L. and Leese, H. (1996). Determinants of oocyte and pre-implantation embryo quality: metabolic requirements and the potential role of cumulus cells. Hum. Reprod. 11 (Suppl): 96–102.Google Scholar
  26. Guerin, P., El Mouatassim, S. and Menezo, Y. (2001). Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum Reprod. Update 7:175–189.PubMedCrossRefGoogle Scholar
  27. Huey, S., Abuhamad, A., Barroso, G., et al. (1999). Perifollicular blood flow Doppler indices, but not follicular pO2, or pH, predict oocyte developmental competence in in vitro fertilization. Fertil.Steril 72:707–712.PubMedCrossRefGoogle Scholar
  28. Jones, G., Trounson, A., Gardner, D., et al (1998). Evolution of a culture protocol for successful blastocyst development and pregnancy. Hum. Reprod. 13:169–177.PubMedCrossRefGoogle Scholar
  29. Kurjak,A., Kupesic-lJrek,S., Schulman H. and Zalud, I. (1991). Transvaginal color flow Doppler in assessment of ovarian and uterine blood flow in inFertile women. Fertil. Steril 60:39–443.Google Scholar
  30. Leese, H. (1998). Human embryo culture: back to nature. J.Assist.Reprod. Genet. 15: 466–468PubMedCrossRefGoogle Scholar
  31. Leese, H. Tay, J., Reischel, and Downing, S. (2001). Formation of fallopian tubal fluid:role of a neglected epithelium. Hum. Reprod.l2:339–346.Google Scholar
  32. MacSweeny, J. Cosgrove, D and Arenson, J. (1996). Color Doppler Energy (Power) mode ultrasound. Clinical Radiology 51: 387–390.CrossRefGoogle Scholar
  33. Menezo, Y and Guerin, P. (1997). The mammalian oviduct: biochemistry and physiology Eur. J. Obstet.Gynaecol. Reprod. Biol. 73:99–104.CrossRefGoogle Scholar
  34. Menezo, Y., Chouteau, J. and Veiga, A. (2001). In vitro fertilization and blastocyst transfer for carrier of chromosome translocation. Eur.J.Obstet.Gynaecol. Reprod. Biol. 96:193–195.CrossRefGoogle Scholar
  35. Menezo. Y., Veiga, A. and Benkhalifa, M. (1998). Improved methods for blastocyst formation and culture. Hum. Reprod. 13(Suppl 4):256–265.PubMedCrossRefGoogle Scholar
  36. Moncayo, H., Penz-Kpza, A., Marth. C., et al.(1998). Vascular endothelial growth factor in serum and in the follicular fluid of patients undergoing hormonal stimulation for in-vitro fertilization. Hum. Reprod. 13: 3310–3314.PubMedCrossRefGoogle Scholar
  37. Nargund, G., Bourne, T., Doyle P., et al (1996a). Associations between ultrasound indices of follicular blood flow, oocyte recovery and preimplantation embryo quality Hum.Reprod. 11: 109–113.PubMedCrossRefGoogle Scholar
  38. Nargund, G., Doyle, P., Bourne, T., et al. (1996b). Ultrasound derived indices of follicular blood flow before HCG administration and the prediction of oocyte recovery and preimplantation embryo quality. Hum. Reprod. 11:2512–2517.PubMedCrossRefGoogle Scholar
  39. Orsi, N. and Leese, H. (2001). Protection against reactive oxygen species during mouse preimplantation embryo development: role of EDTA, oxygen tension, catalase, Superoxide dismutase and pyruvate. Mol. Reprod. Devel. 59: 44–53.PubMedCrossRefGoogle Scholar
  40. Oyesanya, O., Parsons, J., Collins, W. et al (1996). Prediction of oocyte recovery rate by transvaginal ultrasonography and color Doppler imaging before human chorionic gonadotrophin administration in vitro fertilization cycles. Fertil.Steril 65: 806–809.PubMedGoogle Scholar
  41. Pellicer, A., Neuspiller, F., Ardiles G., et al., (1998). Ovarian follicular dynamics: from basic science to clinical practice. J. Reprod. Immunol. 39: 29–61.PubMedCrossRefGoogle Scholar
  42. Redmer, D. Dai, Y., Li, J. et al. (1996). Characterisation and expression of vascular endothelial growth factor (VEGF) in the ovine corpus luteum. J. Reprod. Fertil. 108: 157–165.PubMedCrossRefGoogle Scholar
  43. Rodger, F., Young E., Fraser, H. and Moor, R. (1998). Endothelial cell proliferation follows the mid-cycle luteinising hormone surge but not human chorionic gonadotrophin rescue in the human corpus luteum. Hum. Reprod. 12: 1723–1729.CrossRefGoogle Scholar
  44. Rubin, J., Bude, R.,and Carson, P. et al. (1994). Power Doppler US:A potentially useful alternative to mean frequency based color Doppler ultrasound. Radiology. 190: 853–856.PubMedGoogle Scholar
  45. Rubinstein, M., Marazzi, A. and Polak de Fried, E. (1999). Low dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation and pregnancy rates in patients undergoing in-vitro Fertilization: a prospective randomised double-blind placebo controlled assay. Fertil. Steril 71: 825–829.PubMedCrossRefGoogle Scholar
  46. Scott, L., Alvero, R., Leonides, M., and Miller, H.(2000) The morphology of human pronuclear embryos is positively related to blastocyst development and implantation. Hum Reprod. 15: 2394–2403.PubMedCrossRefGoogle Scholar
  47. Sierra-Honigmann, M., Nath, A., Murakami, C., et.al. (1998). Biological action of leptin as an angiogenic factor. Science 281: 1683–1686.PubMedCrossRefGoogle Scholar
  48. Steer, C., Campbell, S. Tan, S., et.al. (1992). The use of color flow imaging after in vitro fertilization to identify optimum uterine conditions before embryo transfer. Fertil. Steril, 57:372–376.PubMedGoogle Scholar
  49. Strohmer, H., Herczeg, C., Plockinger, B et al. (1991). Prognostic appraisal of success and failure of an in vitro fertilization program by transvaginal Doppler ultrasound at the time of ovulation induction. Ultrasound in Obstet. Gynaecol. 1: 272–274.CrossRefGoogle Scholar
  50. Suzuki, T., Sasano, H., Takaya, R., et.al. (1998). Cyclic changes of vasculature and vascular phenotypes in normal human ovaries. Hum. Reprod. 13: 953–959.PubMedCrossRefGoogle Scholar
  51. Taylor, K., Burns, P., Wells, P., et.al. (1985). Ultrasound Doppler flow studies of the ovarian and uterine arteries. Br.J.Obstet.Gynaecol. 92: 240–246.PubMedCrossRefGoogle Scholar
  52. Taylor, C. and Johnson, P. (1996). Complement binding proteins are strongly expressed by human preimplantation blastocysts and cumulus cells as well as gametes. Mol. Hum. Reprod. 2: 52–59.PubMedCrossRefGoogle Scholar
  53. Tesarik, J., Junca A. Hazout, A., et al. (2000). Embryos with high implantation potential after intracytoplasmic sperm injection can be recognised by a simple non-invasive examination of pronuclear morphology. Hum. Reprod. 15:1396–1399.PubMedCrossRefGoogle Scholar
  54. Van Blerkom, J. (1997). Can the developmental competence of early human embryos be predicted effectively in the clinical IVF laboratory. Hum. Reprod. 12:1610–1614.PubMedCrossRefGoogle Scholar
  55. Van’Blerkom, J., Antczak, M. and Schrade, R. (1997). The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor and perifollicular blood flow characteristics. Hum. Reprod. 12: 1047–1055.CrossRefGoogle Scholar
  56. Van Blerkom, J. (1994). Developmental failure in human reproduction associated with chromosomal abnormalities and cytoplasmic pathologies in meiotically mature oocytes. In: The Biological Basis of Early Reproduction Failure in the Human:Applications to Medically Assisted Conception, Van Blerkom, J. ed Oxford University Press, Oxford, pp 283–325.Google Scholar
  57. Van Blerkom, J. (1996). The influence of intrinsic and extrinsic factors on the development potential and chromosomal normality of the human oocyte. J. Soc. Gynecol. Investig. 3:3–11.PubMedCrossRefGoogle Scholar
  58. Yuval, Y., Lipitz, S., Dor, J. and Achiron, R. (1999) The relationships between endometrial thickness, and blood flow pregnancy rates in in-vitro fertilization. Hum. Reprod. 14:1067–1071.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Linda Gregory
    • 1
  1. 1.Cardiff Assisted Reproduction UnitUniversity Hospital of WalesCardiff WalesUK

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