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KI67, P53, NM23, and DNA Cytometry IN Bladder Cancer: Potential Markers for Detection of Recurrence?

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Bladder Disease, Part A

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Abstract

In Germany, transitional cell carcinoma (TCC) of the urinary bladder is the eighth most common cancer.3 At present, pathological staging and grading are the most significant prognostic variables when planning treatment of TCC; however, the bladder tumor varies greatly in its biologic behavior. Up to 70% of superficial TCC (Ta/Tl) will eventually recur, while 10 to 15% will progress to muscle invasion (≥T2).4 About 50% of patients with muscle-invasive tumors subsequently develop metastases.39,41 Therefore, biological characteristics influence, to a variable extent, the incidence of recurrence, disease-free time, stage progression, and metastatic diffusion of TCC.

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Authors and Affiliations

  1. Department of Urology, Eberhard-Karls-University of Tübingen, Tübingen, Germany

    Gerhard Feil, F. Steffen Krause, Andreas Zumbraegel, Hans W. Wechsel & Karl-H. Bichler

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  1. Gerhard Feil
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  2. F. Steffen Krause
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  4. Hans W. Wechsel
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Editors and Affiliations

  1. Children’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

    Anthony Atala

  2. Ridgefield, Connecticut, USA

    Debra Slade

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Feil, G., Krause, F.S., Zumbraegel, A., Wechsel, H.W., Bichler, KH. (2003). KI67, P53, NM23, and DNA Cytometry IN Bladder Cancer: Potential Markers for Detection of Recurrence?. In: Atala, A., Slade, D. (eds) Bladder Disease, Part A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8889-8_8

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  • DOI: https://doi.org/10.1007/978-1-4419-8889-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4707-1

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