Cystectomy Causes Immunosuppression in Bladder Cancer

  • Ralf Herwig
  • Olaf A. Brinkmann
  • Karl-Dietrich Sievert
  • G. Brodner
  • Lothar Hertle


Bladder cancer is the fourth most common cancer among men and the sixth most common non-cutaneous cancer overall, with 54,200 new cases and 12,000 deaths in 1999 (NCI website). Local treatment may be successful, but tumors commonly reoccur. Tumor invasion into the muscle layer of the bladder wall usually requires total bladder removal. Without metastasis, cystectomy with urinary diversion is the only possible cure for these patients, although the risk for postoperative metastasis development is considerably high.


Natural Killer Bladder Cancer Urinary Diversion Bladder Cancer Patient Peripheral Blood Mononuclear 
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  1. 1.
    Denis MG, Lipart C, Leborgne J, LeHur PA, Galmiche JP, Denis M, et al: Detection of disseminated tumor cells in peripheral blood of colorectal cancer patients. Int J Cancer, 74:540, 1997.PubMedCrossRefGoogle Scholar
  2. 2.
    Fujii Y, Kageyama Y, Kawakami S, Kihara K, Oshima H: Detection of disseminated urothelial cancer cells in peripheral venous blood by a cytokeratin 20-specific nested reverse transcriptase-polymerase chain reaction. Jpn J Cancer Res, 90:753, 1999.PubMedCrossRefGoogle Scholar
  3. 3.
    Hatam L, Schuval S, Bonagura VR: Flow cytometric analysis of natural killer cell function as a clinical assay. Cytometry 16:59, 1994.PubMedCrossRefGoogle Scholar
  4. 4.
    Horan PK, Slezak SE: Stable cell membrane labelling. Nature, 340:167, 1989.PubMedCrossRefGoogle Scholar
  5. 5.
    Jackson A, Warner NL: Preparation, staining and analysis by flow cytometry of peripheral blood leukocytes. In: Rose NR, Friedman H, Fahey JL, editors. Manual of Clinical Laboratory and Immunology, 3rd ed. Washington DC: American Society for Microbiology, p. 226, 1986.Google Scholar
  6. 6.
    Kim CJ, Yuasa T, Kushima R, Tomoyoshi T, Seto A: Antitumor killer lymphocytes in the peripheral blood of a patient with transitional cell carcinoma of the bladder. Int J Urol, 5:230, 1998.PubMedCrossRefGoogle Scholar
  7. 7.
    Radcliff G, Jaroszeski MJ: Basics of flow cytometry. Methods Mol Biol, 91:1, 1998.PubMedGoogle Scholar
  8. 8.
    Robinson JP: Handbook of Flow Cytometry Methods. New York: Wiley-Liss; 1993.Google Scholar
  9. 9.
    Sales JP, Wind P, Douard R, Cugnenc PH, Loric S: Blood dissemination of colonic epithelial cells during no-touch surgery for rectosigmoid cancer. Lancet, 354:392, 1999.PubMedCrossRefGoogle Scholar
  10. 10.
    Slezak SE, Horan PK: Cell-mediated cytotoxicity. A highly sensitive and informative flow cytometric assay. J Immunol Methods, 117:205, 1989.PubMedCrossRefGoogle Scholar
  11. 11.
    Terstappen LW, Rao C, Gross S, Kotelnikov V, Radila E, Uhr J, et al: Flow cytometry-principles and feasibility in transfusion medicine. Enumeration of epithelial derived tumor cells in peripheral blood. Vox Sang, 74(Suppl 2):269, 1998.PubMedCrossRefGoogle Scholar
  12. 12.
    Weitz J, Kienle P, Lacroix J, Willeke F, Benner A, Lehnert T, et al: Dissemination of tumor cells in patients undergoing surgery for colorectal cancer. Clin Cancer Res, 4:343, 1998.PubMedGoogle Scholar
  13. 13.
    Weitz J, Kienle P, Magener A, Koch M, Schrodel A, Willeke F, et al: Detection of disseminated colorectal cancer cells in lymph nodes, blood and bone marrow. Clin Cancer Res, 5:1830, 1999.PubMedGoogle Scholar
  14. 14.
    Wong LS, Cantrill JE, Odogwu S, Morris AG, Fraser IA: Detection of circulating tumour cells and nodal metastasis by reverse transcriptase-polymerase chain reaction technique. Br J Surg 84:834, 1997.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Ralf Herwig
    • 1
  • Olaf A. Brinkmann
    • 1
  • Karl-Dietrich Sievert
    • 1
  • G. Brodner
    • 1
  • Lothar Hertle
    • 1
  1. 1.Department of Urology Department of AnesthesiologyUniversity of MuensterGermany

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