Abstract
Bladder dysfunction secondary to benign prostatic hyperplasia (BPH) is a major affliction of aging men. BPH can initiate both irritative lower urinary tract symptoms (urgency, frequency, and nocturia), and obstructive symptoms (reduced flow rate, increased micturition pressure, increased duration of micturition, and incomplete emptying). Although these symptoms are related to the effect of the enlarging prostate and subsequent urethral obstruction, there appears to be no direct relationship between prostate size or composition and severity of symptoms.3,13,17,19,23 In addition, the results of standard urodynamic evaluations do not correlate well with the severity of patient symptoms; standard urodynamics cannot accurately predict either level of bladder pathology or potential for recovery following surgery.3,13,17,19,23 One major problem is that current methods of urodynamic analysis, including pressure measurements, are indirect assessments of detrusor power or contractile function.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brackman F, Autet W: Once and twice daily dosage regimens of Pygeum africanum extract (PA): a double blind study in patients with benign prostatic hyperplasia. J Urol, 161(Suppl 4):361, 1999.
Gosling JA, Gilpin SA, Dixon JS, Gilpin CJ: Decrease in the autonomic innervation of human detrusor muscle in outflow obstruction. J Urol, 136(2):501, 1986.
Ichiyanagi O, Nakada T: Correlations between parameters in pressure-flow analysis and histological compositions in prostate in patients with benign prostatic hyperplasia. Urol Int, 59(3):154, 1997.
Jørgensen JB, Jensen KM-E: Uroflowmetry. Urol Clin North America, 23(2):237, 1996.
Levin RM, Longhurst PA, Monson FC, Kato K, Wein AJ: Effect of bladder outlet obstruction on the morphology, physiology and pharmacology of the bladder. Prostate, 3(Suppl):9, 1990.
Levin RM, Longhurst PA, Monson FC, Haugaard N, Wein AJ: Experimental studies on bladder outlet obstruction. In: Lepor H, Lawson RK, editors. Prostate Diseases. Philadelphia: WB Saunders Company, p. 119–130, 1993.
Levin RM, Levin SS, Zderic SA, Yoon JY, Wein AJ: Effect of partial outlet obstruction of the rabbit urinary bladder on ryanodine binding to microsomal membranes. Gen Pharmacol, 25(3):421, 1994.
Levin RM, Zderic SA, Yoon JY, Sillen U, Wein AJ: Effect of ryanodine on the contractile response of the normal and hypertrophied rabbit urinary bladder to field stimulation. Pharmacology, 47(4):244, 1993.
Levin RM, Riffaud J-P, Bellamy F, Rohrmann D, Habib M, Krasnopolsky L, et al: Protective effect of Tadenan on bladder function secondary to partial outlet obstruction. J Urol, 155:1466, 1996.
Levin RM, Riffaud J-P, Bellamy F, Rohrmann D, Krasnopolsky L, Haugaard N, et al: Effects of Tadenan pretreatment on bladder physiology and biochemistry following partial outlet obstruction. J Urol, 156:2084, 1996.
Levin RM, Das AK, Haugaard N, Novitsky Y, Horan P, Leggett RE, et al: Beneficial effects of Tadenan therapy after two weeks of partial obstruction in the rabbit. Neurourol urodyn, 16(6):583, 1997.
Levin RM, Haugaard N, Hogavero L, Leggett RE, Das AK: Biochemical evaluation of obstructive bladder dysfunction in men secondary to BPH: a preliminary report. Urology, 53(2):446, 1999.
Levin RM, Haugaard N, Hypolite JA, Wein AJ, Buttyan R: Metabolic factors influencing lower urinary tract function. Exp Physiol, 84(1):171, 1999.
Longhurst PA, Wein AJ, Levin RM: In-vitro models of bladder contraction and function. Neurourol. Urodyn, 10:97, 1991.
Rohrmann D, Levin RM, Duckett JW, Zderic SA: The decompensated detrusor I: the effects of bladder outlet obstruction on the use of intracellular stores. J Urol, 156(2 Pt 2):578, 1996.
Schäfer W: Principles and clinical application of advanced urodynamic analysis of voiding function. Urol Clin North America, 17(3):553, 1990.
Shapiro E, Lepor H: The pathophysiology of clinical BPH. Prog Clin Biol Res, 386:253, 1994.
Steers WD, De Groat WC: Effect of bladder outlet obstruction on micturition reflex pathways in the rat. J Urol, 140(4):864, 1988.
Terris MK, Afzal N, Kabalin JN: Correlation of transrectal ultrasound measurements of prostate and transition zone size with symptom score, bother score, urinary flow rate, and post-void residual volume. Urology, 52(3):462, 1998.
Valentini FA, Nelson PP: A general model of skeletal muscular contraction Part II: Introduction of he activation parameter and the nervous control. Kybernetes, 14:241, 1985.
Valentini F, Besson G, Malavaud B, Nelson P, Saby M-O, Sarramon J-P: A mathematical model of micturition applied to the interpretation of uroflowmetry curves of patients with benign prostatic hypertrophy. J Urol, 155(5):382A, 1996.
Valentini FA, Besson GR, Nelson PP, Zimmern PE: A mathematical micturition model to restore simple flow recordings in healthy and symptomatic individuals and enhance uroflow interpretation. Neurourol Urodyn, 19:153, 2000.
Witjes WP, Aarnink RG, Ezz-el-Din K, Wijkstra H, Debruyne EM, de la Rosette JJ: The correlation between prostate volume, transition zone volume, transition zone index and clinical and urodynamic investigations in patients with lower urinary tract symptoms. Br J Urol, 80(1):84, 1997.
Zderic SA, Rohrmann D, Gong C, Snyder HM, Duckett JW, Wein AJ, Levin RM: The decompensated detrusor II: evidence for loss of sarcoplasmic reticulum function after bladder outlet obstruction in the rabbit. J Urol, 156(2 Pt 2):587, 1996.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Valentini, F.A., Levin, R.M., Besson, G.R., Nelson, P.P. (2003). Study of Detrusor Dysfunction Due to Outlet Obstruction: Link Between Analysis of Uroflows of Men with Benign Prostatic Hyperplasia and Animal Studies. In: Atala, A., Slade, D. (eds) Bladder Disease, Part A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8889-8_22
Download citation
DOI: https://doi.org/10.1007/978-1-4419-8889-8_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4707-1
Online ISBN: 978-1-4419-8889-8
eBook Packages: Springer Book Archive