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Achieving Appropriate Glycosylation During the Scaleup of Antibody Production

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Antibodies

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Abstract

Glycosylation is the most extensive and variable of mammalian posttranslational modifications with profound implications for folding, stability, pharmacokinetics, antigenicity and biological activity of proteins. In the last several decades, improvements in the technology for analyzing protein glycosylation and measuring its biological effects have revolutionized the discipline of “glycobiology”. Thus, extremely subtle alterations in glycoproteins can now be detected, and appropriate modifications brought about which were nearly impossible 20 years ago.

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Authors and Affiliations

  1. Meridian Bioscience, 3471 River Hills Drive, Cincinnati, OH, 45244, USA

    X. K. Deng & K. John Morrow Jr

  2. CarboWorld, 1010 Haddon Drive, San Mateo, CA, 94402, USA

    T. Shantha Raju

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  1. X. K. Deng
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  1. Littlebourne, Kent, UK

    G. Subramanian

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Deng, X.K., Shantha Raju, T., Morrow, K.J. (2004). Achieving Appropriate Glycosylation During the Scaleup of Antibody Production. In: Subramanian, G. (eds) Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8877-5_3

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  • DOI: https://doi.org/10.1007/978-1-4419-8877-5_3

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