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Angiogenesis in transgenic models of multistep angiogenesis

  • Chapter
Book cover Angiogenesis in Brain Tumors

Part of the book series: Cancer Treatment and Research ((CTAR,volume 117))

Abstract

The histopathology and the epidemiology of human cancers, as well as studies of animal models of tumorigenesis, have led to a widely accepted notion that multiple genetic and epigenetic changes have to accumulate for progression to malignancy. Formation of new blood vessels (tumor angiogenesis) has been recognized, in addition to proliferative capabilities and ability to downmodulate cell death (apoptosis), as essential for the progressive growth and expansion of solid tumors. Mice overexpressing activated forms of oncogenes or carrying targeted mutations in tumor suppressor genes have proven extremely useful for linking the function of these genes with specific tumor features such as continuous proliferation, escape from apoptosis, invasion and neo-angiogenesis, The interbreeding of these mice allows for studying the extent of cooperativity between different genetic lesions in disease progression, leading to a greater understanding of multi-stage nature of tumorigenesis.

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Authors and Affiliations

  1. Institute of Neuropathology, University Hospital of Zürich, Zürich, Switzerland

    Ivan Radovanovic, Maria G. D’Angelo & Adriano Aguzzi

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  1. Ivan Radovanovic
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  2. Maria G. D’Angelo
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  3. Adriano Aguzzi
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Editors and Affiliations

  1. Neurosurgery Carl Gustav Carus Hospital, Technical University of Dresden, Dresden, Germany

    Matthias Kirsch

  2. Neurosurgery Children’s Hospital Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Peter McL. Black

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Radovanovic, I., D’Angelo, M.G., Aguzzi, A. (2004). Angiogenesis in transgenic models of multistep angiogenesis. In: Kirsch, M., Black, P.M. (eds) Angiogenesis in Brain Tumors. Cancer Treatment and Research, vol 117. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8871-3_5

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  • DOI: https://doi.org/10.1007/978-1-4419-8871-3_5

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  • Print ISBN: 978-1-4613-4699-9

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