Abstract
The puromycin-sensitive aminopeptidase (ApPS) was identified as the major enkephalin-degrading activity in brain, but has subsequently been implicated in a variety of cellular functions. In addition to regulating the concentration of neuropeptides, ApPS has been suggested to be involved in reproductive function, cell cycle regulation, regulation of apoptosis, general protein turnover, and antigen presentation. Its involvement in these cellular functions has led to its implication in a number of diseases and disorders, including reproductive infertility, adult-onset dementia, disorders of anxiety and nociception, cancer and metastasis, growth defects, liver failure, and disorders of immune function. While its involvement in these disease states is evident, the precise pathology of these conditions is unknown, making the identification of physiological substrates of ApPS and the development of specific ApPS inhibitors an attractive field of study.
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Thompson, M.W., Hersh, L.B. (2004). The Puromycin-Sensitive Aminopeptidase. In: Hooper, N.M., Lendeckel, U. (eds) Aminopeptidases in Biology and Disease. Proteases in Biology and Disease, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8869-0_1
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