Yeast Signal Transduction: Regulation and Interface with Cell Biology

  • George F. Sprague
  • Paul J. Cullen
  • April S. Goehring
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 547)


We examined the morphogenetic transitions that yeast cells undergo in response to extracellular cues, and determined that multiple mechanisms control specificity of signal transduction pathway signaling and the attendant physiological response that ensues. This article describes the approaches that we used to determine these mechanisms. Our findings indicate that scaffolding proteins, which organize signal transduction pathways, are an especially powerful means to achieve specificity. We do not yet know how general this mechanism is. Our studies have also started to reveal ways in which a protein, Ste20, first identified as a participant in signal transduction pathways, may also connect to the basic cell biology machinery. Synthetic lethal genetic analysis has suggested that the polarisome and a new ubiquitin-like system may be targets of Ste20.


Yeast Cell Signal Transduction Pathway Scaffolding Protein Filamentous Growth Microscopic Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • George F. Sprague
    • 1
  • Paul J. Cullen
    • 1
  • April S. Goehring
    • 1
  1. 1.Institute of Molecular BiologyUniversity of OregonEugene

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