A novel C3-like ADP-ribosyltransferase produced by Clostridium limosum
Various strains of Clostridium botulinum type C and D produce the exoenzyme C3 (1, 2, 3) which ADP-ribosylates the small GTP-binding proteins rho (4, 5) and rac (6). C3 is encoded by phages which also encode the structural gene for botulinum neurotoxins (7, 8). However, it is now generally accepted that C3 is structurally, immunologically and functionally distinct from the neurotoxins (9). Here we report on the purification and characterization of a novel C3-like ADP-ribosyltrans-ferase produced by Clostridium limosum, which modifies small GTP-binding proteins.
KeywordsPlatelet Membrane Botulinum Neurotoxin Proteolytic Peptide Acceptor Amino Acid Human Platelet Membrane
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