Abstract
Neoplastic cells have an imbalance in the control of their growth and differentiation pathways. Because signal transduction constitutes a critical component of differentiation-induction, the nature of the enzymes involved in this process is important and are being actively examined. Another important question is the nature of the gene changes that cause the cellular alterations and their mechanism. Although the precise mechanism of transformation and DNA repair in mammalian cells has not been elucidated, poly(ADP-ribose) synthesis has been noted for its close correlation to carcinogenesis and DNA repair. Poly ADPR transferase is an eukaryotic nuclear enzyme which catalyses the successive transfer of ADP-ribose moiety of NAD+ to various nuclear proteins. A sudden increase in polymer can lead to rapid consumption of NAD+ and ATP and therefore can prevent or delay cell proliferation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Boyum, A. (1968) Isolation of mononuclear cells and granulocyte from human blood. Scand J Clin Lab Invest Suppl 21: 77–90.
Jacobson, M.K., Levi, V., Juarez Salinas, H., Barton, K.A., Jacobson, E.L. (1980) Effect of carcinogenic N alkyl-N-nitroso compounds on nicotinamide adenine dinucleotide metabolism. Cancer Res 40: 1797–1802.
Ikai, K., Ueda, K., Fukushima, M., Nakamura, T., Hayaishi, O. (1980) Poly(ADP-ribose)synthesis, a marker of granulocyte differentiation. Proc Natl Acad Sci USA 77: 682–3685.
Hirai, K., Ueda, K., Hayaishi, O. (1983) Aberration of poly(Adenosine diphosphate-ribose) metabolism in human colon adenomatous polyp and cancer. Cancer Res 43: 3441–3446.
Miwa, M., Oda, K., Segawa, K., Tanaka, M., Sugimura, T. (1977) Cell density dependent increase in chromatin associated ADP-ribosyl transferase activity in simian virus 40-transformed cells. Arch Biochem Biophys 181: 313–321.
Durkacz, B.W., Omidiji, O., Gray, D.A., Shall, S. (1980) (ADP-ribose) participates in DNA excision repair. Nature 283: 593–596.
Jacobson, E.L., Lange, R.A., Jacobson, M.K. (1979) Pyridine nucleotide synthesis in 3T3 cells. J Cell Physiol 99: 417–426.
Carson, D.A., Seto, S., Wasson, D.B. (1987) Pyridine nucleotide cycling and poly(ADP-ribose) synthesis in resting hyuman lymphocytes. J. Immunol 138: 1904–1907.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this paper
Cite this paper
Singh, N., Rudra, N., Bansal, P. (1992). Induction of Poly ADP-Ribosylation in Human Malignant Cells. In: Poirier, G.G., Moreau, P. (eds) ADP-Ribosylation Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8718-1_45
Download citation
DOI: https://doi.org/10.1007/978-1-4419-8718-1_45
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-6456-9
Online ISBN: 978-1-4419-8718-1
eBook Packages: Springer Book Archive