Expression of poly (ADP-ribose) polymerase in differentiating HL-60 cells

  • Pierre Moreau
  • Guy Poirier
  • Scott Kaufmann
Conference paper

Abstract

Poly (ADP-ribose) polymerase (PARP) is a zinc finger protein that is activated by binding to DNA single-or double-strand breaks (reviewed in Althaus et al., 1987). Studies with inhibitors have suggested that PARP plays a role in homologous and heterologous recombination as well as DNA repair, These processes are closely associated to cell differentiation and proliferation. To better understand the regulation of PARP activity during cellular differentiation, we have determined the PARP mRNA and protein levels during the granulocytic differentiation of HL-60 cells induced by DMSO.

Keywords

Zinc Migration DMSO Recombination Polypeptide 

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References

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Pierre Moreau
  • Guy Poirier
  • Scott Kaufmann

There are no affiliations available

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