The Expression of ICAM-1 and P-Selectin Are Increased Following Hemorrhage and Resuscitation in Mice
Acute inflammatory lung injury is a common clinical occurrence following trauma and blood loss and is characterized by massive neutrophil infiltration into the lungs. The mechanisms responsible for the increased susceptibility to acute lung injury remain incompletely understood. P-selectin and ICAM-1, two types of adhesion molecules, have been shown to participate in several forms of neutrophil-dependent lung injury. In order to examine the mechanisms which contribute to trafficking of neutrophils in the lungs and development of pulmonary injury following blood loss, we investigated in-vivo mRNA and immunohistochemical expression of P-selectin and ICAM-1 following hemorrhage and resuscitation.
KeywordsLung Injury Acute Lung Injury Alveolar Epithelium Cytokine Gene Transcription Consecutive Tissue Section
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