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Map Kinases in Airway Disease: Standing at the Confluence of Basic and Clinical Science

  • Paul Vichi
  • James Posada
Chapter
Part of the NATO ASI Series book series (NSSA, volume 297)

Abstract

Mitogen activated protein (MAP) kinases are a family of serineJthreonine protein kinases that currently include three major subgroups; the extracellular regulated kinase 2 (ERK2), the c-Jun NH2 terminal kinase (JNK), and the p38 kinase. Each of the three major subgroups of MAP kinase has additional isozymes (reviewed in 1). For example, there are three ERK isozymes, and up to 10 JNK isozymes, including differentially processed transcripts2. The nomenclature of the JNK MAP kinases is somewhat disjoined owing primarily to the contemporaneous cloning of these kinases. Kyriakis et al. cloned what they termed stress activated protein kinases (SAPK) α, β, γ, which are identical to the JNK MAP kinases cloned by Derijard et al.3.

Keywords

Mitogen Activate Protein Kinase Airway Smooth Muscle Adult Respiratory Distress Syndrome Airway Smooth Muscle Cell Mitogen Activate Protein Kinase Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1998

Authors and Affiliations

  • Paul Vichi
    • 1
  • James Posada
    • 1
  1. 1.Department of Molecular Physiology BurlingtonUniversity of Vermont College of MedicineVermontUSA

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