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Acute Respiratory Distress Syndrome pp 177–186Cite as

Map Kinases in Airway Disease: Standing at the Confluence of Basic and Clinical Science

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Part of the book series: NATO ASI Series ((NSSA,volume 297))

Abstract

Mitogen activated protein (MAP) kinases are a family of serineJthreonine protein kinases that currently include three major subgroups; the extracellular regulated kinase 2 (ERK2), the c-Jun NH2 terminal kinase (JNK), and the p38 kinase. Each of the three major subgroups of MAP kinase has additional isozymes (reviewed in 1). For example, there are three ERK isozymes, and up to 10 JNK isozymes, including differentially processed transcripts2. The nomenclature of the JNK MAP kinases is somewhat disjoined owing primarily to the contemporaneous cloning of these kinases. Kyriakis et al. cloned what they termed stress activated protein kinases (SAPK) α, β, γ, which are identical to the JNK MAP kinases cloned by Derijard et al.3.

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Authors and Affiliations

  1. Department of Molecular Physiology Burlington, University of Vermont College of Medicine, Vermont, 05405, USA

    Paul Vichi & James Posada

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  1. Paul Vichi
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  2. James Posada
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Editors and Affiliations

  1. The University of Alabama at Birmingham, Birmingham, Alabama, USA

    Sadis Matalon

  2. University of Illinois at Chicago, Chicago, Illinois, USA

    Jacob Lasha Sznajder

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© 1998 Plenum Press, New York

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Vichi, P., Posada, J. (1998). Map Kinases in Airway Disease: Standing at the Confluence of Basic and Clinical Science. In: Matalon, S., Sznajder, J.L. (eds) Acute Respiratory Distress Syndrome. NATO ASI Series, vol 297. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8634-4_22

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  • DOI: https://doi.org/10.1007/978-1-4419-8634-4_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45830-9

  • Online ISBN: 978-1-4419-8634-4

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