Surfactant Replacement in Patients with Ards: Results of Clinical Trials

  • Roger G. Spragg
  • Robert M. Smith
Part of the NATO ASI Series book series (NSSA, volume 297)


Since the first medical description of the acute respiratory distress syndrome (ARDS) three decades ago, there has been growing evidence that disturbance of the lung surfactant system may contribute to the pathophysiology of that syndrome. Initial descriptions of patients with ARDS documented abnormalities of lung surfactant biophysical function. Understanding of the complexity of the lung surfactant system has matured, and it is now possible to describe both biophysical and non-biophysical functions of that system, how the various components of lung surfactant may be altered in disease states, and how those alterations may contribute to lung surfactant dysfunction. Such understanding forms a rational basis for design and evaluation of studies of lung surfactant administration to patients with ARDS.


Acute Lung Injury Acute Respiratory Distress Syndrome Adult Respiratory Distress Syndrome Surfactant Protein Pulmonary Surfactant 
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Copyright information

© Plenum Press, New York 1998

Authors and Affiliations

  • Roger G. Spragg
    • 1
  • Robert M. Smith
    • 1
  1. 1.Department of MedicineUniversity of California San Diego VA Medical CenterSan DiegoUSA

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