Large-scale Multiple Model for the Simulation of Anesthesia

  • R. Q. Y. Tham
  • F. J. Sasse
  • V. C. Rideout
Part of the Advances in Simulation book series (ADVS.SIMULATION, volume 3)


During anesthesia, many interacting factors (both intrinsic and extrinsic to the physiological system) affect hemodynamic responses and equilibria. Cardiovascular parameters, which are intrinsic factors of the physiological system regulating the hemodynamic responses, constantly adjust to maintain metabolic demand. External factors such as drug actions exert their influence directly on the cardiovascular parameters, and indirectly through the baroreceptor, chemoreceptor, and hormonal regulators to alter the cardiovascular parameter values and hemodynamic responses. Interactions among the drug actions and the cardiovascular system are complex and varied, producing different responses between and within species. One example of such variations arises with the multiple sites of actions of halothane as identified by [Seag 85], accounting for some inconsistent observations in heart rate and systemic peripheral resistances responses that occur during halothane anesthesia.


Multiple Model Parasympathetic Activity Carotid Sinus Halothane Anesthesia Cardiovascular Parameter 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • R. Q. Y. Tham
    • 1
  • F. J. Sasse
    • 1
  • V. C. Rideout
    • 1
  1. 1.Department of Electrical and Computer Engineering and Department of AnesthesiologyUniversity of Wisconsin-MadisonUSA

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