Prediction of Amplitude and Frequency Dependence of the Backscatter Coefficient in Cancellous Bone with An Autocorrelation Model
QUS measurements represent an established means of bone status assessment in osteoporosis1. Currently available technologies are based on measurements in transmission of the slope of the frequency-dependent attenuation (BUA in dB/MHz) and the speed of sound (SOS in m/s) at peripheral skeletal sites (calcaneus, finger phalanges). The QUS approach in osteoporosis has been clinically validated: the predictive value of QUS for fracture risk at the femoral neck and spine has been documented in several prospective studies2,3. However, the potential of QUS for bone characterization is still not fully exploited. Transmission measurements only partially exploit the information related to the interaction between the elastic wave and bone micro architecture. Several studies concluded that ultrasonic measurements on human cancellous bones reflected primarily bone mineral density (BMD) and that there was only limited room for micro-structural factors to play a role in current QUS measurements4,5.
KeywordsFrequency Dependence Autocorrelation Function Bone Mass Density Backscatter Coefficient Human Cancellous Bone
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