Prediction of Amplitude and Frequency Dependence of the Backscatter Coefficient in Cancellous Bone with An Autocorrelation Model

  • Frédéric Padilla
  • Nicolas Rossignol
  • Françoise Peyrin
  • Pascal Laugier
Part of the Acoustical Imaging book series (ACIM, volume 26)


QUS measurements represent an established means of bone status assessment in osteoporosis1. Currently available technologies are based on measurements in transmission of the slope of the frequency-dependent attenuation (BUA in dB/MHz) and the speed of sound (SOS in m/s) at peripheral skeletal sites (calcaneus, finger phalanges). The QUS approach in osteoporosis has been clinically validated: the predictive value of QUS for fracture risk at the femoral neck and spine has been documented in several prospective studies2,3. However, the potential of QUS for bone characterization is still not fully exploited. Transmission measurements only partially exploit the information related to the interaction between the elastic wave and bone micro architecture. Several studies concluded that ultrasonic measurements on human cancellous bones reflected primarily bone mineral density (BMD) and that there was only limited room for micro-structural factors to play a role in current QUS measurements4,5.


Frequency Dependence Autocorrelation Function Bone Mass Density Backscatter Coefficient Human Cancellous Bone 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Frédéric Padilla
    • 1
  • Nicolas Rossignol
    • 1
  • Françoise Peyrin
    • 2
  • Pascal Laugier
    • 1
  1. 1.Laboratoire d’Imagerie ParamétriqueParisFrance
  2. 2.Creatis UMR INSA 502Villeurbanne CedexFRANCE

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