Abstract
Because of the important impact of atherosclerosis on public health, the evaluation of the potential evolution of atherosclerotic lesions and their response to interventional therapy is a subject of much current concern. Studies in vitro have demonstrated that the ultimate biological behavior of an atherosclerotic plaque depends, not only on its extent, but also on its biochemical composition and structure.1 An in vivo means for identifying the composition and structure of atherosclerotic plaques would be useful in guiding diagnosis and treatment. Using appropriate signal analysis methods, the acoustic attenuation and the backscatter coefficient may be estimated from echographic signals.2 These parameters are related to tissue structure and composition and may therefore, offer additional quantitative information useful for the characterization of atherosclerotic plaques.3−12 We have recently described a method for the construction of quantitative images using local estimations of the attenuation and the apparent integrated backscatter.11 The current work examines the sensitivity of measurements of the ultrasonic attenuation and the apparent integrated backscatter (30 to 50 MHz) to differences in the local tissue composition in the arterial wall (collagen, lipids, calcifications, and media).
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References
R.T. Lee, S.G. Richardson, H.M. Loree et al. Prediction of mechanical properties of human atherosclerotic tissue by high-frequency intravascular ultrasound imaging: An in vitro study, Arteriosclerosis and Thrombosis. 12:1(1992).
2.-V. Roberjot, S.L. Bridal, P. Laugicr, and G. Berger, Absolute backscatter coefficient over a wide range of frequencies in a tissue-mimicking phantom containing two populations of scatterers, IEEE Trans UFFC. 43:970(1996).
B. Barzilai, J.E. Saffitz, J.G. Miller, and B.E. Sobcl, Quantitative ultrasonic characterization of the nature of atherosclerotic plaques in human aorta, Circ Res. 60:459(1987).
M.P. Urbani, E. Picano, G. Parenti et al, In vivo radiofrequency-based ultrasonic tissue characterization of the atherosclerotic plaque, Stroke. 24:1507(1993).
J.F. Greenleaf, F.A. Duck, W.F. Samayoa, and S.A. Johnson, Ultrasonic data acquisition and processing system for atherosclerotic tissue characterization, IEEE Ultrason Symp. 74 CH0896-ISU:738(1974).
E. Picano, L. Landini, A. Distante et al, Fibrosis, lipids, and calcium in human atherosclerotic plaque: In vitro differentiation from normal aortic walls by ultrasonic attenuation, Circ Res. 56:556(1985).
G.R. Lockwood, L.K. Ryan, J.W. Hunt, and F.S. Foster, Measurement of the ultrasonic properties of vascular tissues and blood from 35-65 MHz, Ultrasound Med Biol. 17:653(1991).
M.G.M. DeKroon, L.F. van der Wal, W.J. Gussenhoven, H. Rijstcrborgh, and N. Bom, Backscatter directivity and integrated backscatter power of arterial tissue, Int J of Cardiac Imaging. 6:265(1991).
L.S. Wilson, M.L. Neale, H.E. Talhami, and M. Applcbcrg, Preliminary results from attenuation-slope mapping of plaque using intravascular ultrasound, Ultrasound Med Biol. 20:529(1994).
S.A. Wickline, J.G. Miller, D. Recchia et al, Beyond intravascular imaging: Quantitative ultrasonic tissue characterization of vascular pathology. IEEE Ultrasonics Symposium. 3:1589(1994).
S.L. Bridal, P. Fornès, P. Bruneval, and G. Berger, Parametric (integrated backscatter and attenuation) images constructed using backscattcred radio frequency signals (25 to 56 MHz) from human aortae in vitro, Ultrasound Med Biol. 23:215(1997).
S.L. Bridal, P. Fornès, P. Bruneval, and G. Berger, Correlation of Ultrasonic Attenuation (30 to 50 MHz) and Constituents of Atherosclerotic Plaque, Ultrasound Med Biol. in press(1997).
M. Fink, F. Hottier, and J.F. Cardoso, Ultrasonic signal processing for in vivo attenuation measurement: Short time Fourier analysis, Ultrasonic Imaging. 5:117(1983).
M. Ueda and Y. Ozawa, Spectral analysis of echoes for backscattering coefficient measurement, J. Acoust Soc Amer. 77:38(1985).
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© 1997 Springer Science+Business Media New York
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Lori Bridal, S., Fornès, P., Berger, G. (1997). Relationship Between Ultrasonic Attenuation, Apparent Integrated Backscatter (30 To 50 Mhz) and the Composition of Atherosclerotic Plaque. In: Lees, S., Ferrari, L.A. (eds) Acoustical Imaging. Acoustical Imaging, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8588-0_29
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DOI: https://doi.org/10.1007/978-1-4419-8588-0_29
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