Use of Fibrin Glues in the Surgical Treatment of Incisional Hernias

  • J. P. Chevrel
  • A. M. Rath


In the 1900s the advantages of the adhesive properties of fibrin were investigated in the form of a blood clot applied to a wound for hemostasis and adhesion. An autologous plasma glue, rich in fibrinogen and thrombin, was used in 1940 for nerve anastomosis. The fibrinogen was not sufficiently concentrated, however, and normal fibrinolysis destroyed the glue. It was only in 1972, in Vienna, that Matras et al. used a very concentrated cryoprecipitated fibrin glue for nerve anastomosis in an animal model and in humans. Its safety and effectiveness made it attractive for a wide variety of surgical indications, and new generations of fibrin sealants quickly developed in response to these demands.


Incisional Hernia Fibrin Glue Bovine Spongiform Encephalopathy Factor Xiii Fibrin Sealant 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • J. P. Chevrel
    • 1
  • A. M. Rath
    • 2
  1. 1.Service de Chirurgie Générale et Digestive Hôpital AvicenneBobignyFrance
  2. 2.Serivce de Chirurgie Générale et DigestiveHôpital de BobignyBobignyFrance

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