An Overview on Animal Models of ALL

  • Michael A. Batey
  • Josef H. Vormoor


Further advances in the understanding of the molecular processes essential for the development, spread, and survival of cancer cells are leading to the identification and validation of new targets for anti-cancer therapy. It is imperative that the pace of screening and drug development technology can keep up, so as to enable the transfer of interesting hypotheses into useful drugs in patients. One of the challenges facing leukemia research is the development and validation of clinically relevant animal models of disease, both to improve our understanding of the mechanisms involved, and to provide reliable efficacy testing for new therapeutic agents. In recent years, a great deal of progress has been made in this field. This chapter hopes to summarise these studies, and looks forward in the future modelling of acute lymphoblastic leukemia.


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia SCID Mouse Gemtuzumab Ozogamicin Leukemic Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2011 2011

Authors and Affiliations

  1. 1.Northern Institute for Cancer ResearchNewcastle University, Sir James Spence InstituteNewcastle Upon TyneUK

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