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Biennial Review of Infertility pp 197–210Cite as

ART and Epigenetic Disorders: Should We Be Concerned?

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Abstract

An ART treatment cycle – comprising a basic sequence of ovarian ­stimulation, oocyte retrieval, embryo culture, and transfer – is, by conventional measures, a routine and comparatively safe medical intervention. The greatest risks from ART derive from the complications associated with multiple pregnancies. Yet, studies indicate that even a singleton pregnancy from ART confers greater health risks than that of natural conceptions. In this section, we review the established associations of ART to rare epigenetic disorders of imprinting. The biologic mechanisms through which epigenetic programming might be altered within the process of ART are examined. The still unknown long-term health associations of ART past 30 years are considered in the framework of emerging and increasing compelling evidence that environmental conditions during the early development are an important determinant of health during later adult years.

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Acknowledgment

This work is supported by NICHD grant R01 HD 062803 - 01 A1 to PFR.

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Authors and Affiliations

  1. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA

    Paolo F. Rinaudo

Authors
  1. Christopher N. Herndon
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  2. Paolo F. Rinaudo
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Correspondence to Paolo F. Rinaudo .

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Editors and Affiliations

  1. Brigham & Women's Hospital, Dept. Obstetrics & Gynecology, Harvard Medical School, Francis St. 75, Boston, 02115, Massachusetts, USA

    Catherine Racowsky

  2. Weill Cornell Medical Center, Dept. Urology, New York Presbyterian Hospital, East 68th St. 525, New York, 10021, New York, USA

    Peter N. Schlegel

  3. , Department of Reproductive Medicine, University Medical Center Utrecht, PO Box 85500, Utrecht, 3508 GA, Netherlands

    Bart C. Fauser

  4. Departments of Surgery (Urology), Obstetrics & Gynecology & Physiology, Andrology and IVF Laboratories, Arapeen Dr. 675, Salt Lake City, 84108, Utah, USA

    Douglas T. Carrell

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Herndon, C.N., Rinaudo, P.F. (2011). ART and Epigenetic Disorders: Should We Be Concerned?. In: Racowsky, C., Schlegel, P., Fauser, B., Carrell, D. (eds) Biennial Review of Infertility. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8456-2_14

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  • DOI: https://doi.org/10.1007/978-1-4419-8456-2_14

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