Signaling Cross-Talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer

  • Xiaodong ChengEmail author


Oncogenic transformation is the result of a complex process that involves multiple steps of genetic and cellular alterations, most notably the activation of oncogenes and the inactivation of tumor suppressor genes. Great advances have been made in identifying genetic alterations associated with various human cancers in recent years. The discovery of signaling cross-talk between KRAS and Hedgehog signaling, the two universally dysregulated pathways in pancreatic cancer, provides new insights into understanding the mechanism of pancreatic tumorigenesis and potential novel therapeutic strategy for treating this deadly disease.


Pancreatic Ductal Adenocarcinoma Pancreatic Ductal Adenocarcinoma Cell Pancreatic Progenitor Cell Human Pancreatic Ductal Adenocarcinoma Human Pancreatic Ductal Epithelium 
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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Pharmacology and ToxicologyThe University of Texas Medical BranchGalvestonUSA

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