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Hedgehog signaling activation in human cancer and its clinical implications pp 49–64Cite as

Kinases and Phosphatases in Hedgehog Signaling

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Abstract

The study of posttranslational regulation of proteins has occupied biochemists for well over a half century. Understanding balanced phosphorylation and dephosphorylation of the proteins may be the key to meeting some of the most pressing scientific challenges. A detailed examination of the phosphorylation of many components in Hedgehog (Hh) pathway is leading to a better understanding of the Hh signaling mechanisms. This chapter describes the precise phosphorylation that evolves the phosphorylation/dephosphorylation of the players in Hh signaling cascade, including the signal transducer Smoothened and the transcription factor Ci/Gli.

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  1. Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky College of Medicine, 741 South Limestone, BBSRB Rm 373, Lexington, KY, 40536-0509, USA

    Jianhang Jia

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  1. University of Texas Medical Branch, Galveston, 77555, Texas, USA

    Jingwu Xie

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Jia, J. (2011). Kinases and Phosphatases in Hedgehog Signaling. In: Xie, J. (eds) Hedgehog signaling activation in human cancer and its clinical implications. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8435-7_4

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