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Small-Molecule Inhibitors of the Hedgehog Pathway

  • Ari J. Firestone
  • James K. ChenEmail author
Chapter

Abstract

The causal link between uncontrolled Hedgehog (Hh) pathway activation and oncogenesis has inspired the development of small-molecule inhibitors of this developmental signaling pathway. In this chapter, we discuss how a cyclopia-inducing natural product isolated in the 1950s has engendered a pharmacopoeia of compounds that block Hh target gene expression. We describe how these Hh pathway inhibitors were discovered, their mechanisms of action, and their potential as anti-cancer agents. We also examine potential limitations of current approaches and future directions for Hh pathway-targeting chemotherapies.

Keywords

Primary Cilium Betulinic Acid Nevoid Basal Cell Carcinoma Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Chemical and Systems BiologyStanford University School of MedicineStanfordUSA

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