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Overview of Hedgehog Signaling Pathway

  • Chi-chung HuiEmail author
  • Jin Jiang
Chapter
  • 522 Downloads

Abstract

Initially discovered in Drosophila and later found in all vertebrate model organisms, the Hedgehog (Hh) family of secreted proteins plays critical roles in both embryonic development and adult tissue homeostasis [41, 84]. Numerous human genetic disorders and cancer have been associated with aberrant Hh signaling activity [41, 63, 84].

Keywords

Primary Cilium Ciliary Localization Ciliary Entry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

C. C. H. is supported by the Canadian Cancer Society Research Institute, and J. J. is supported by grants from NIH, CPRIT, and Welch Foundation (I-1603). We thank Julie Yu for help in illustrations.

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Program in Developmental and Stem Cell BiologyThe Hospital for Sick ChildrenTorontoCanada
  2. 2.Department of Molecular GeneticsUniversity of TorontoTorontoCanada

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