Mechanisms and Current Research

Chapter

Abstract

Until recently, primary cicatricial alopecias had received little attention in the clinical and research realm. With the dramatic increases in our knowledge of basic hair biology, new and powerful tools have become available to study these rare disorders in ways that were previously not possible. As we have moved from traditional clinical studies and histopathology to molecular biology, new paradigms regarding the pathophysiology of cicatricial alopecia have been developed. However, after clarifying many previously unanswered questions, we are faced with a series of new and unanswered ones. By the time this publication is completed, new information will be available, and we encourage the reader to stay tuned and engaged as research in cicatricial alopecia continues to unfold.

Keywords

Sebotrophic hypothesis Research in cicatricial alopecia Animal models (in research) Hair follicle stem cells Epidermal stem cells Immunology Peroxisomes Lipid metabolic pathways PPAR-gamma 

Suggested Reading

  1. Evers B, Farooqi MS, Shelton JM, et al. Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin. J Invest Dermatol. 2010;130:1237–48.PubMedCrossRefGoogle Scholar
  2. Karnik P, Tekeste Z, McCormick TS, et al. Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. J Invest Dermatol. 2009;129:1243–57.PubMedCrossRefGoogle Scholar
  3. Stenn K, Karnik P. Lipids to the top of hair biology. J Invest Dermatol. 2010;130:1205–7.PubMedCrossRefGoogle Scholar
  4. Wan Y, Saghatelian A, Chong L, et al. Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. Genes Dev. 2007;21:1895–1908.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of DermatologyUniversity of California, San FranciscoSan FranciscoUSA
  2. 2.Department of DermatologyCase Western Reserve UniversityClevelandUSA
  3. 3.Department of DermatologyThe Permanente Medical GroupVallejoUSA

Personalised recommendations