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Narcolepsy pp 47–60Cite as

Histamine in Narcolepsy and Excessive Daytime Sleepiness

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Abstract

Central histaminergic neurotransmission, originating from the tuberomammillary nucleus (TMN) in the posterior hypothalamus, constitutes one of the most important wake-active systems (see [1, 2] for review). Similar to other monoaminergic systems, histaminergic neurons consist of almost ubiquitous and long projections, a characteristic of neuronal circuits that are involved in vigilance control. Histaminergic neurons are active, and histamine release is high during wakefulness [3, 4]. There is evidence that histaminergic neurotransmission is interacting with other sleep–wake regulatory systems to mediate physiological wakefulness and other physiological functions during wakefulness [1, 2]. However, we do not well understand how the histaminergic system interacts with other sleep–wake regulatory systems, and how these systems are harmonized.

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Authors and Affiliations

  1. Stanford Center for Sleep Sciences, Stanford University School of Medicine, 1201 Welch Road, P213, Palo Alto, CA, 94304, USA

    Seiji Nishino

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  1. Seiji Nishino
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Correspondence to Seiji Nishino .

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Editors and Affiliations

  1. , Department of Neurology, University Hospital of Zurich, Frauenklinikstrasse 26, Zurich, 8091, Switzerland

    Christian R. Baumann

  2. Neurocenter EOC of Southern Switzerland, Department of Neurology, University Hospital Zurich, Via Tesserete 46, Lugano, 6903, Switzerland

    Claudio L. Bassetti

  3. and Harvard Medical School, Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, 02215, Massachusetts, USA

    Thomas E. Scammell

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Nishino, S. (2011). Histamine in Narcolepsy and Excessive Daytime Sleepiness. In: Baumann, C., Bassetti, C., Scammell, T. (eds) Narcolepsy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8390-9_5

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  • DOI: https://doi.org/10.1007/978-1-4419-8390-9_5

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