Skip to main content
SpringerLink
Log in

Translational Research on Irreversible Electroporation: VX2 Rabbit Head and Neck

  • Chapter
  • First Online:
Clinical Aspects of Electroporation

Abstract

Head and neck cancers account for a small percent of new cancer cases each year in comparison to other cancers. However, the diagnosis of this disease is usually life threatening and negatively impacts the quality of the patient’s life. With various treatments or therapies available for the different stages of squamous cell carcinoma of the head and neck (SCCHN), the most prominent type of head and neck cancer, significant side effects or disadvantages such as severe toxicity and lack of organ preservation sometimes outweigh the positive outcomes. Irreversible electroporation (IRE) is a novel treatment that is currently showing promise in tumor ablation without the disadvantages of other techniques. Therefore, current research is underway in order to utilize IRE against implanted VX2 rabbit tumors in the head and neck region to demonstrate its effectiveness. Through preliminary results, positive outcomes are showing great promise that IRE may be the next innovative treatment for SCCHN.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Gold KA, Lee HY, Kim ES. Targeted therapies in squamous cell carcinoma of the head and neck. Cancer. 2009;115(5):922–35.

    Article  PubMed  CAS  Google Scholar 

  2. Osaki T, Hirota J, Yoneda K, Yamamoto T, Ueta E. Distribution of surviving tumor cells after chemoradiotherapy in tongue and floor of mouth carcinomas. Head Neck. 1994;16(3):218–26.

    Article  PubMed  CAS  Google Scholar 

  3. Batsakis JG. Surgical excision margins: a pathologist’s perspective. Adv Anat Pathol. 1999;6(3):140–8.

    Article  PubMed  CAS  Google Scholar 

  4. Woolgar JA. T2 carcinoma of the tongue: the histopathologist’s perspective. Br J Oral Maxillofac Surg. 1999;37(3):187–93.

    Article  PubMed  CAS  Google Scholar 

  5. Jain P, Kumar P, Pai VR, Parikh PM. Neoadjuvant chemotherapy or chemoradiotherapy in head and neck cancer. Indian J Cancer. 2008;45(3):83–9.

    Article  PubMed  Google Scholar 

  6. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin. 2007;57(1):43–66.

    Article  PubMed  Google Scholar 

  7. Lango MN. Multimodal treatment for head and neck cancer. Surg Clin North Am. 2009;89(1):43–52; viii.

    Google Scholar 

  8. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000;92(9):709–20.

    Article  PubMed  CAS  Google Scholar 

  9. Seiwert TY, Salama JK, Vokes EE. The chemoradiation paradigm in head and neck cancer. Nat Clin Pract Oncol. 2007;4(3):156–71.

    Article  PubMed  CAS  Google Scholar 

  10. Kim ES, Kies M, Herbst RS. Novel therapeutics for head and neck cancer. Curr Opin Oncol. 2002;14(3):334–42.

    Article  PubMed  CAS  Google Scholar 

  11. Vokes EE et al. Head and neck cancer. N Engl J Med. 1993;328(3):184–94.

    Article  PubMed  CAS  Google Scholar 

  12. Lee JJ, Hah JH, Im SA, Kim SY, Sung MW, Kim KH, et al. Neoadjuvant chemotherapy followed by limited surgery in a mouse model of head and neck cancer. Anticancer Res. 2009;29(1):255–9.

    PubMed  CAS  Google Scholar 

  13. Gilbert RW. Innovation in the surgical management of head and neck tumors. Hematol Oncol Clin North Am. 2008;22(6):1181–91; viii-ix.

    Google Scholar 

  14. Crile G. Landmark article Dec 1, 1906: excision of cancer of the head and neck. With special reference to the plan of dissection based on one hundred and thirty-two operations. By George Crile. JAMA. 1987;258(22):3286–93.

    Article  PubMed  CAS  Google Scholar 

  15. Pignon JP, Bourhis J, Domenge C, Designé L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet. 2000;355(9208):949–55.

    PubMed  CAS  Google Scholar 

  16. Harari PM. Epidermal growth factor receptor inhibition strategies in oncology. Endocr Relat Cancer. 2004;11(4):689–708.

    Article  PubMed  CAS  Google Scholar 

  17. Karamouzis MV, Grandis JR, Argiris A. Therapies directed against epidermal growth factor receptor in aerodigestive carcinomas. JAMA. 2007;298(1):70–82.

    Article  PubMed  CAS  Google Scholar 

  18. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567–78.

    Article  PubMed  CAS  Google Scholar 

  19. Maor E, Ivorra A, Leor J, Rubinsky B. Irreversible electroporation attenuates neointimal formation after angioplasty. IEEE Trans Biomed Eng. 2008;55(9):2268–74.

    Article  PubMed  Google Scholar 

  20. Rubinsky J, Onik G, Mikus P, Rubinsky B. Optimal parameters for the destruction of prostate cancer using irreversible electroporation. J Urol. 2008;180(6):2668–74.

    Article  PubMed  Google Scholar 

  21. Bertacchini C, Margotti PM, Bergamini E, Lodi A, Ronchetti M, Cadossi R. Design of an irreversible electroporation system for clinical use. Technol Cancer Res Treat. 2007;6(4):313–20.

    PubMed  Google Scholar 

  22. Onik G, Mikus P, Rubinsky B. Irreversible electroporation: implications for prostate ablation. Technol Cancer Res Treat. 2007;6(4):295–300.

    PubMed  Google Scholar 

  23. Lee EW, Chen C, Prieto VE, Dry SM, Loh CT, Kee ST. Advanced hepatic ablation technique for ­creating complete cell death: irreversible electroporation. Radiology. 2010;255(2):426–33.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, B2-168, Los Angeles, CA, 90095-1721, USA

    Daphne Wong

Authors
  1. Daphne Wong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Edward W. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stephen T. Kee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daphne Wong .

Editor information

Editors and Affiliations

  1. Division of Interventional Radiology, Department of Radiology, Ronald Reagan Medical Center at UCLA, 757 Westwood Plaza, RM2125, Los Angeles, 90095, California, USA

    Stephen T. Kee

  2. , Department of Oncology, Copenhagen University Hospital Herlev, Herlev Ringvej 75, Herlev, 2730, Denmark

    Julie Gehl

  3. Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, B2-168 10833, Los Angeles, 90095, California, USA

    Edward W. Lee

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Wong, D., Lee, E.W., Kee, S.T. (2011). Translational Research on Irreversible Electroporation: VX2 Rabbit Head and Neck. In: Kee, S., Gehl, J., Lee, E. (eds) Clinical Aspects of Electroporation. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8363-3_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-8363-3_20

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-8362-6

  • Online ISBN: 978-1-4419-8363-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation