Translational Research on Irreversible Electroporation: VX2 Rabbit Head and Neck

Chapter

Abstract

Head and neck cancers account for a small percent of new cancer cases each year in comparison to other cancers. However, the diagnosis of this disease is usually life threatening and negatively impacts the quality of the patient’s life. With various treatments or therapies available for the different stages of squamous cell carcinoma of the head and neck (SCCHN), the most prominent type of head and neck cancer, significant side effects or disadvantages such as severe toxicity and lack of organ preservation sometimes outweigh the positive outcomes. Irreversible electroporation (IRE) is a novel treatment that is currently showing promise in tumor ablation without the disadvantages of other techniques. Therefore, current research is underway in order to utilize IRE against implanted VX2 rabbit tumors in the head and neck region to demonstrate its effectiveness. Through preliminary results, positive outcomes are showing great promise that IRE may be the next innovative treatment for SCCHN.

Keywords

Irreversible electroporation VX2 Head and neck cancer Squamous cell carcinoma of the head and neck Chemo-radiotherapy Epidermal growth factor receptor 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Interventional Radiology, Department of RadiologyDavid Geffen School of Medicine at UCLALos AngelesUSA

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