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Clinical Aspects of Electroporation pp 129–135Cite as

Drug and Gene Electrotransfer to the Brain

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Abstract

Applying drugs and genes to brain tissue using electroporation is a new and upcoming field of research. Because of the blood brain barrier (BBB), the access of agents from the blood into brain tissue is restricted. This could theoretically be overcome by the use of electroporation. In the early 1990s, the first pre-clinical experiments using electrochemotherapy in brain tissue were conducted in rats with inoculated brain tumours; however, the technique has not yet been further explored and applied in humans. This chapter will focus on the pre-clinical experience with drug and gene electrotransfer in the brain, the clinical experience with use of bleomycin in the brain, and the following clinical perspectives. Further discussion of central issues, such as safety and the BBB, will also be discussed.

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Author information

Authors and Affiliations

  1. University of Copenhagen, Copenhagen, Denmark

    Julie Gehl

  2. Center for Experimental Drug and Gene Electrotransfer (C*EDGE), Department of Oncology 54B1, Copenhagen University Hospital Herlev, Herlev Ringvej 75, 2730, Herlev, Denmark

    Julie Gehl

Authors
  1. Birgit Agerholm-Larsen
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  2. Mette Linnert
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  3. Helle K. Iversen
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  4. Julie Gehl
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Corresponding author

Correspondence to Julie Gehl .

Editor information

Editors and Affiliations

  1. Division of Interventional Radiology, Department of Radiology, Ronald Reagan Medical Center at UCLA, 757 Westwood Plaza, RM2125, Los Angeles, 90095, California, USA

    Stephen T. Kee

  2. , Department of Oncology, Copenhagen University Hospital Herlev, Herlev Ringvej 75, Herlev, 2730, Denmark

    Julie Gehl

  3. Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, B2-168 10833, Los Angeles, 90095, California, USA

    Edward W. Lee

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© 2011 Springer Science+Business Media, LLC

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Agerholm-Larsen, B., Linnert, M., Iversen, H.K., Gehl, J. (2011). Drug and Gene Electrotransfer to the Brain. In: Kee, S., Gehl, J., Lee, E. (eds) Clinical Aspects of Electroporation. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8363-3_11

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  • DOI: https://doi.org/10.1007/978-1-4419-8363-3_11

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-8362-6

  • Online ISBN: 978-1-4419-8363-3

  • eBook Packages: MedicineMedicine (R0)

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