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Management: Cirrhotic Portal Hypertension

Chapter

Abstract

Gastroesophageal varices are a direct consequence of portal hypertension, the main complication of cirrhosis. An understanding of the pathophysio­logy of portal hypertension has led to significant improvements in the prevention and treatment of variceal hemorrhage. However, variceal hemorrhage continues to carry a significant mortality. By screening all patients with cirrhosis for varices, applying prophylaxis appropriately, actively managing acute variceal hemorrhage, and aggressively preventing recurrence, survival can be improved. Future directions include better risk stratification for a more individualized care, determining the role of noninvasive markers of varices and portal pressure and the development of novel pharmacotherapeutic agents.

Keywords

Variceal hemorrhage Esophagogastric varices Cirrhosis Portal hypertension 

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Copyright information

© Springer New York 2011

Authors and Affiliations

  1. 1.Section of Digestive DiseasesYale University School of MedicineNew HavenUSA
  2. 2.Section of Digestive DiseasesVA Connecticut Health Care SystemWest HavenUSA

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