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Optical Sensing of Red Blood Cell Dynamics

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Mechanobiology of Cell-Cell and Cell-Matrix Interactions

Abstract

Human red blood cell membrane (RBC) has remarkable deformability, which is crucial for its oxygen transportation in the blood circulatory system. This deformability of the RBC membrane can be altered by several patho-physiological conditions. Here we present recent development of optical imaging techniques to measure dynamic fluctuations in the RBC membrane, from which RBC membrane mechanical properties are probed non-invasively.

This chapter is part of Section IV: Tools for Exploring Mechanobiology

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Acknowledgements

The authors are grateful for the mentoring provided by the late Michael Feld. The authors acknowledge fruitful collaborations with the groups lead by Subra Suresh, Alex Levine, Nir Gov, and Sam Safran.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, Quantitative Light Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA

    Gabriel Popescu

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  1. YongKeun Park
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  2. Catherine A. Best
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  3. Gabriel Popescu
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Correspondence to Gabriel Popescu .

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  1. , Department of Mechanical & Industrial, University of Illinois, Urbana-Champaign, 1206 W. Green St., Urbana, 61801, Illinois, USA

    A. Wagoner Johnson

  2. , Department of Chemical & Biomolecular, University of Illinois, Urbana-Champaign, 600 S. Mathews Ave., Urbana, 61801, Illinois, USA

    Brendan A.C. Harley

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Park, Y., Best, C.A., Popescu, G. (2011). Optical Sensing of Red Blood Cell Dynamics. In: Wagoner Johnson, A., Harley, B. (eds) Mechanobiology of Cell-Cell and Cell-Matrix Interactions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8083-0_13

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