Beetle Immunity

  • Ji-Won Park
  • Chan-Hee Kim
  • Jiang Rui
  • Keun-HwaPark
  • Kyung-Hwa Ryu
  • Jun-Ho Chai
  • Hyun-Ok Hwang
  • Kenji Kurokawa
  • Nam-Chul Ha
  • Irene Söderhäll
  • Kenneth Söderhäll
  • Bok Luel Lee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 708)


Genetic studies have elegantly characterized the innate immune response in Drosophila melanogaster. However, these studies have a limited ability to reveal the biochemical mechanisms underlying the innate immune response. To investigate the biochemical basis of how insects recognize invading microbes and how these recognition signals activate the innate immune response, it is necessary to use insects, from which larger amounts of hemolymph can be extracted. Using the larvae from two species of beetle, Tenebrio molitor and Holotrichia diomphalia, we elucidated the mechanisms underlying pathogenic microbe recognition. In addition, we studied the mechanism of host defense molecule amplification. In particular, we identified several pattern recognition proteins, serine proteases, serpins and antimicrobial peptides and examined how these molecules affect innate immunity.


Coleopteran Insect Clip Domain Stal Structure Holotrichia Diomphalia 


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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ji-Won Park
    • 1
  • Chan-Hee Kim
    • 1
  • Jiang Rui
    • 1
  • Keun-HwaPark
    • 1
  • Kyung-Hwa Ryu
    • 1
  • Jun-Ho Chai
    • 1
  • Hyun-Ok Hwang
    • 1
  • Kenji Kurokawa
    • 1
  • Nam-Chul Ha
    • 1
  • Irene Söderhäll
    • 2
  • Kenneth Söderhäll
    • 2
  • Bok Luel Lee
    • 1
  1. 1.National Research Laboratory of Defense Proteins, College of PharmacyPusan National UniversityBusanKorea
  2. 2.Department of Comparative PhysiologyUppsala UniversityUppsalaSweden

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