Skip to main content

Histamine in Normal and Malignant Cell Proliferation

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 709))

Abstract

Histamine is a biogenic amine widely distributed throughout the body. Given the observations that histamine can be induced and made available in an unstored diffusible form in tissues undergoing rapid growth (such as tumors and regenerating liver), it could have a role beyond inflammatory and allergic responses.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brenna E, Tielemans Y, Kleveland PM et al. Effect of the histamine-2 agonist impromidine on stem cell proliferation of rat oxyntic mucosa. Scand J Gastroenterol 1995; 30:311–314.

    Article  PubMed  CAS  Google Scholar 

  2. Morini G, Grandi D, Schunack W. Ligands for histamine H(3) receptors modulate cell proliferation and migration in rat oxyntic mucosa. Br J Pharmacol 2002; 137:237–244.

    Article  PubMed  CAS  Google Scholar 

  3. Chen G, Kashiwagi H, Omura N et al. Effect of a histamine H1 receptor antagonist on gastric endocrine cell proliferation induced by chronic acid suppression in rats. J Gastroenterol 2000; 35:742–747.

    Article  PubMed  CAS  Google Scholar 

  4. Modlin IM, Zhu Z, Tang LH et al. Evidence for a regulatory role for histamine in gastric enterochromaffin-like cell proliferation induced by hypergastrinemia. Digestion 1996; 57:310–321.

    Article  PubMed  CAS  Google Scholar 

  5. Ciacci C, Zarrilli R, Ricci V et al. Histamine H2-receptor antagonists stimulate proliferation but not migration of human gastric mucosal cells in-vitro. Dig Dis Sci 1996; 41:972–978.

    Article  PubMed  CAS  Google Scholar 

  6. Byron JW. Mechanism for histamine H2-receptor induced cell-cycle changes in the bone marrow stem cell. Agents Actions 1977; 7:209–213.

    Article  PubMed  CAS  Google Scholar 

  7. Nakaya N, Tasaka K. The influence of histamine on precursors of granulocytic leukocytes in murine bone marrow. Life Sci 1988; 42:999–1010.

    Article  PubMed  CAS  Google Scholar 

  8. Endo Y, Kikuchi T, Takeda Y et al. GM-CSF and G-CSF stimulate the synthesis of histamine and putrescine in the hematopoietic organs in-vivo. Immunol Lett 1992; 33:9–13.

    Article  PubMed  CAS  Google Scholar 

  9. Schneider E, Piquet-Pellorce C, Dy M. New role for histamine in interleukin-3-induced proliferation of hematopoietic stem cells. J Cell Physiol 1990; 143:337–343.

    Article  PubMed  CAS  Google Scholar 

  10. Piquet-Pellorce C, Schneider E, Dy M. GM-CSF in association with IL-1 triggers day-8 CFU-S into cell cycle: role of histamine. J Cell Physiol 1991; 149:18–23.

    Article  PubMed  CAS  Google Scholar 

  11. Kawanami O, Ferrans VJ, Fulmer JD et al. Ultrastructure of pulmonary mast cells in patients with fibrotic lung disorders. Lab Invest 1979; 40:717–734.

    PubMed  CAS  Google Scholar 

  12. Haslam PL, Cromwell O, Dewar A et al. Evidence of increased histamine levels of lung lavage fluids from patients with cryptogenic fibrosing alveolitis. Clin Exp Immunol 1981; 44:587–593.

    PubMed  CAS  Google Scholar 

  13. Franzen, Norrby K. Local mitogenic effect of tissue mast cell secretion. Cell Tissue Kinet 1980; 13:635–642.

    PubMed  CAS  Google Scholar 

  14. Jordana M, Befus AD, Newhouse MT et al. Effect of histamine on proliferation of normal human adult lung fibroblasts. Thorax 1988; 43:552–558.

    Article  PubMed  CAS  Google Scholar 

  15. Leonardi A, Radice M, Fregona IA et al. Histamine effects on conjunctival fibroblasts from patients with vernal conjunctivitis. Exp Eye Res 1999; 68:739–746.

    Article  PubMed  CAS  Google Scholar 

  16. Garbuzenko E, Nagler A, Pickholtz D et al. Human mast cells stimulate fibroblast proliferation, collagen synthesis and lattice contraction: a direct role for mast cells in skin fibrosis. Clin Exp Allergy 2002; 32:237–246.

    Article  PubMed  CAS  Google Scholar 

  17. Kierska D, Fogel W, Maslinski C. Histamine concentration and metabolism in mouse mammary gland during estrous cycle. Inflamm Res 1997; 46:63–64.

    Article  Google Scholar 

  18. Maslinski C, Kierska D, Fogel WA et al. Histamine: its metabolism and localization in mammary gland. Comp Biochem Physiol C 1993; 105:269–273.

    Article  PubMed  CAS  Google Scholar 

  19. Paria B, Das N, Das S et al. Histidine decarboxylase gene in the mouse uterus is regulated by progesterone and correlates with uterine differentiation for blastocyst implantation. Endocrinology 1998; 139:3958–3966.

    Article  PubMed  CAS  Google Scholar 

  20. Davio C, Cricco G, Bergoc RM et al. H1 and H2 histamine receptors in experimental carcinomas with an atypical coupling to signal transducers. Biochem Pharmacol 1995; 50:91–96.

    Article  PubMed  CAS  Google Scholar 

  21. Malviya R, Morrison AR, Pentland AP. Histamine in human epidermal cells is induced by ultraviolet light injury. J Invest Dermatol 1996; 106:75–79.

    Article  Google Scholar 

  22. Maurer M, Optiz M, Henz BM et al. The mast cells product histamine and serotonine stimulate and TNF-alpha inhibits the proliferation of murine epidermal keratinocytes in situ. J Dermatol Sci 1997; 16:79–84.

    Article  PubMed  CAS  Google Scholar 

  23. Shinoda S, Kameyoshi Y, Hide M et al. Histamine enhances UVB-induced IL-6 production by human keratinocytes. Arch Dermatol Res 1998; 290:428–438.

    Article  Google Scholar 

  24. Fitzsimons C, Engel N, Policastro L et al. Regulation of phospholipase C activation by the number of H2 recepotrs during Ca2+-induced differentiation of mouse keratinocytes. Biochem Pharmacol 2002; 63:1785–1796.

    Article  PubMed  CAS  Google Scholar 

  25. Bartholeyns J, Fozard J. Role of histamine in tumor development. Trends Pharmacol Sci 1985; 6:123–125.

    Article  CAS  Google Scholar 

  26. Garcia-Caballero M, Neugebauer E, Rodriguez F et al. Histamine synthesis and content in benign and malignant breast tumors. Its effects on other host. Surg Oncol 1994; 3:167–173.

    Article  PubMed  CAS  Google Scholar 

  27. Falus A, Hegyesi H, Lazar-Molnar E et al. Paracrine and autocrine interactions in melanoma: histamine is a relevant player in local regulation. Trends Immunol 2001; 22:648–652.

    Article  PubMed  CAS  Google Scholar 

  28. Cricco GP, Davio CA, Martin G et al. Histamine as an autocrine growth factor in experimental mammary carcinomas. Agents Actions 1994; 43:17–20.

    Article  PubMed  CAS  Google Scholar 

  29. Wang LD, Wang M, Todisco A et al. The human histamine H(2) receptor regulates c-jun and c-fos in a differential manner. Am J Physiol Cell Physiol 2000; 278:C1246–C1255.

    PubMed  CAS  Google Scholar 

  30. Adams WJ, Lawson JA, Morris DL. Cimrtidine inhibits in-vivo growth of human colon-cancer and reverses histamine-stimulated in-vitro and in-vitro growth. Gut 1994; 35:1632–1636.

    Article  PubMed  CAS  Google Scholar 

  31. Hegyesi H, Somlai B, Varga VL et al. Suppression of melanoma cell proliferation by histidine decarboxylase specific antisense oligonucleotides. J Invest Dermatol 2001; 117:151–153.

    Article  PubMed  CAS  Google Scholar 

  32. Mitsuhashi M, Mitsuhashi T, Payan DG. Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells. J Biol Chem 1989; 264:18356–18362.

    PubMed  CAS  Google Scholar 

  33. Cricco G, Martín G, Labombarda F et al. Human pancreatic carcinoma cell line pane-1 and the role of histamine in growth regulation. Inflammation Res 2000; 49:68–69.

    Article  Google Scholar 

  34. Martín G, Cricco G, Darvas Z et al. Histamine inhibits proliferation of a pancreatic carcinoma cell line without inducing apoptosis significantly. Inflamm Res 2002; 51:S67–S68.

    PubMed  Google Scholar 

  35. Gespach C, Cost H, Abita JP. Histamine H2 receptor activity during the differentiation of human monocytic-like cell line U937. FEBS Lett 1985; 184:207–213.

    Article  PubMed  CAS  Google Scholar 

  36. Shayo C, Davio C, Brodsky A et al. Histamine modulates the expression of c-fos through H2 receptor on the human monocytic cell line U937. Mol Pharmacol 1997; 51:983–990.

    PubMed  CAS  Google Scholar 

  37. Tilly BC, Tertoolen LG, Remorie R et al. Histamine as a growth factor and chemoattractant for human carcinoma and melanoma cells: action through Ca2(+)-mobilizing H1 receptors. J Cell Biol 1990; 110:1211–1215.

    Article  PubMed  CAS  Google Scholar 

  38. Hernandez-Angeles A, Soria-Jasso LE, Ortega A et al. Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. J Neurooncol 2001; 55:81–89.

    Article  PubMed  CAS  Google Scholar 

  39. Valencia S, Hernandez-Angeles A, Soria-Jasso LE et al. Histamine H(1) receptor activation inhibits the proliferation of human prostatic adenocarcinoma DU-145 cells. Prostate 2001; 48:179–187.

    Article  PubMed  CAS  Google Scholar 

  40. Cricco G, Engel N, Croci M et al. Fluoromethylhistidine inhibits tumor growth without producing depletion of endogenous histamine, Inflammation Research 1997; 46:56–59.

    Article  Google Scholar 

  41. Bartholeyns J, Bouclier M. Involvement of histamine in growth of mouse and rat tumors: antitumor properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase. Cancer Res 1984; 44:639–645.

    PubMed  CAS  Google Scholar 

  42. Fitzsimons C, Molinari B, Davio C et al. Atypical association of histamine receptors to signal transductional pathways during multistage carcinogenesis in mouse skin. Inflammation Research 1997; 46:292–298.

    Article  PubMed  CAS  Google Scholar 

  43. Fitzsimons C, Durán H, Labombarda F et al. Histamine receptors signaling in epidermal tumor cell lines with H-ras gene alterations. Inflammation Research 1997; 47:S50–S51.

    Article  Google Scholar 

  44. Pos Z, Safrany G, Muller K et al. Phenotypic profiling of engineered mouse melanomas with manipulated histamine production identifies histamine H2 receptor and rho-C as histamine-regulated melanoma progression markers. Cancer Res 2005; 65:4458–4466.

    Article  PubMed  CAS  Google Scholar 

  45. Pos Z, Wiener Z, Pocza P et al. Histamine Suppresses Fibulin-5 and Insulin-like Growth Factor-II Receptor Expression in Melanoma Cancer Res 2008; 68:1997–2005.

    CAS  Google Scholar 

  46. Cricco G, Davio C, Bergoc RM et al. Inhibition of tumor growth induced by histamine in-vivo and in-vitro studies. Agents Actions 1993; 38:75–78.

    Article  Google Scholar 

  47. Takahashi K, Tanaka S, Ichikawa A. Effect of cimetidine on intratumoural cytokine expression in an experimental tumor. Biochem Biophys Res Commun 2001; 281:1113–1119.

    Article  PubMed  CAS  Google Scholar 

  48. Szincsak N, Hegyesi H, Hunyadi J et al. Cimetidine and a tamoxifen derivative reduce tumor formation in SCID mice xenotransplanted with a human melanoma cell line. Melanoma Res 2002; 12:231–240.

    Article  PubMed  CAS  Google Scholar 

  49. Sheehan PF, Baker T, Tutton PJ et al. Effects of histamine and 5-hydroxytryptamine on the growth rate of xenografted human bronchogenic carcinomas. Clin Exp Pharmacol Physiol 1996; 23:465–471.

    Article  PubMed  CAS  Google Scholar 

  50. Reynolds JL, Akhter JA, Magarey CJ et al. Histamine in human breast cancer. Br J Surg 1998; 85:538–541.

    Article  PubMed  CAS  Google Scholar 

  51. Davio C, Cricco G, Bergoc R et al. H1 and H2 Histamine receptors in human mammary carcinomas. Agents Actions, Special Conference Issue 1993; 38:71–74.

    Google Scholar 

  52. Reynolds JL, Akhter J, Adams WJ et al. Histamine content in colorectal cancer. Are there sufficient levels of histamine to affect lymphocyte function? Eur J Surg Oncol 1997; 23:224–227.

    Article  PubMed  CAS  Google Scholar 

  53. Garcia-Caballero M, Neugebauer E, Campos R et al. Increased histidine decarboxylase (HDC) activity in human colorectal cancer: results of a study on ten patients. Agents Actions 1988; 23:357–360.

    Article  PubMed  CAS  Google Scholar 

  54. Bowrey PF, King J, Magarey C et al. Histamine, mast cells and tumor cell proliferation in breast cancer: does preoperative cimetidine administration have an effect? Br J Cancer 2000; 82:167–170.

    Article  PubMed  CAS  Google Scholar 

  55. Kobayashi K, Matsumoto S, Morishima T et al. Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression. Cancer Res 2000; 60:3978–3984.

    PubMed  CAS  Google Scholar 

  56. Boer K, Helinger E, Helinger A et al. Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumors by histamine. Eur J Cell Biol 2008; 87:227–236.

    Article  PubMed  CAS  Google Scholar 

  57. Cianchi F, Cortesini C, Schiavone N et al. The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. Clin Canc Res 2005; 11:6807–6815.

    Article  CAS  Google Scholar 

  58. Graff L, Frungieri M, Zanner R et al. Expression of histidine decarboxylase and synthesis of histamine by human small cell lung carcinoma. Am J Pathol 2002; 160:1561–1565.

    Article  PubMed  CAS  Google Scholar 

  59. Kondratenko TY, Zacharova IV, Katukov VYu et al. The study of histamine H1-and H2-receptors in human lung cancer. Biochem Mol Biol Int 1993; 31:399–404.

    PubMed  CAS  Google Scholar 

  60. Belcheva A, Mishkova R. Histamine content in lymph nodes from patients with malignant lymphomas. Inflamm Res 1995; 44:S86.

    Article  PubMed  CAS  Google Scholar 

  61. Malaviya R, Uckun FM. Histamine as an autocrine regulator of leukemic cell proliferation. Leuk Lymphoma 2000; 36:367–373.

    Article  PubMed  CAS  Google Scholar 

  62. Burtin C, Noirot C, Paupe J et al. Decreased blood histamine levels in patients with solid malignant tumors. Br J Cancer 1983; 47:367–372.

    Article  PubMed  CAS  Google Scholar 

  63. Sabolovic D, Dubravcic D, Culo F et al. Histamine levels in the blood in patients with malignant tumors. Lijec Vjesn 1989; 111:185–187.

    PubMed  CAS  Google Scholar 

  64. Previati M, Raspadori A, Bertolaso L et al. Determination of histamine in the whole blood of colon cancer patients. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 780:331–339.

    Article  PubMed  CAS  Google Scholar 

  65. Norrby K. Mast cells and angiogenesis. APMIS 2002; 110:355–371.

    Article  PubMed  CAS  Google Scholar 

  66. Norrby K. Evidence of a dual role of endogenous histamine in angiogenesis. Int J Exp Pathol 1995; 76:87–92.

    PubMed  CAS  Google Scholar 

  67. Fraser RA, Simpson JG. Role of mast cells in experimental tumor angiogenesis. In: Development of the Vascular System (Ciba Foundation Symposium 100). London: Pitman, 1983:120–131.

    Google Scholar 

  68. Ghosh AK, Hirasawa N, Ohuchi K. Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H2 receptors. Br J Pharmacol 2001; 134:1419–1428.

    Article  PubMed  CAS  Google Scholar 

  69. Ghosh AK, Hirasawa N, Ohtsu H et al. Defective angiogenesis in the inflammatory granulation tissue in histidine decarboxylase-deficient mice but not in mast cell-deficient mice. J Exp Med 2002; 195:973–982.

    Article  PubMed  CAS  Google Scholar 

  70. Kanda N, Watanabe S. Histamine Inhibits the Production of Interferon-induced Protein of 10 kDa in Human Squamous Cell Carcinoma and Melanoma. J Invest Dermatol 2002; 119:1411–1419.

    Article  PubMed  CAS  Google Scholar 

  71. Elenkov IJ, Chrousos GP, Wilder RL. Neuroendocrine regulation of IL-12 and TNF-alpha/IL-10 balance. Clinical implication Ann N Y Acad Sci 2000; 917:94–105.

    Article  CAS  Google Scholar 

  72. Idzko M, la Sala A, Ferrari D et al. Expression and function of histamine receptors in human monocyte-derived dendritic cells. J Allergy Clin Immunol 2002; 109:839–846.

    Article  PubMed  CAS  Google Scholar 

  73. Takahashi K, Tanaka S, Furuta K et al. Histamine H(2) receptor-mediated modulation of local cytokine expression in a experimental tumor. Biochem Biophys Res Commun 2002; 297:1205–1210.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andras Falus .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Landes Bioscience and Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Falus, A., Pós, Z., Darvas, Z. (2010). Histamine in Normal and Malignant Cell Proliferation. In: Thurmond, R.L. (eds) Histamine in Inflammation. Advances in Experimental Medicine and Biology, vol 709. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8056-4_11

Download citation

Publish with us

Policies and ethics