Insights into the Aetiology of Ovotesticular DSD from Studies of Mouse Ovotestes

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 707)


In mammals, Sry (sex-determining region Y gene) is the master regulator of male sex determination. It induces a cascade of gene expression that regulates the differentiation of the bipotential genital ridges into testicular tissue. In the absence of Sry, or if SRY function is impaired, the genital ridges develop into ovaries. Subsequently, hormones produced by the testes and ovaries direct the differentiation of all secondary sexual characteristics (for review, see Wilhelm and Koopman [1]).


Sertoli Cell Testicular Tissue Secondary Sexual Characteristic Sock Gene Genital Ridge 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Institute for Molecular Biosciences, The University of QueenslandBrisbaneAustralia

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