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Bacterial Quorum Sensing and Its Interference: Methods and Significance

  • Iqbal Ahmad
  • Mohd Sajjad Ahmad KhanEmail author
  • Fohad Mabood Husain
  • Maryam Zahin
  • Mahipal Singh
Chapter

Abstract

Bacteria use the language of low-molecular-weight ligands to assess their population densities in a process called quorum sensing (QS). Different types of quorum sensing pathways are present in Gram-negative and Gram-positive bacteria. Signal molecules most commonly used in Gram-negative bacteria are acyl homoserine lactones. In recent years, a substantial amount of literature and data have been available on bacterial QS. Recently, interest in modulation of quorum sensing with different approaches has increased among scientific communities. In this chapter, we provide an updated overview on bacterial QS, assays and methods for detecting signal molecules, and various approaches to inhibit AHL-based quorum sensing. Significance of QS interference by prokaryotic and eukaryotic organisms in relation to plant health and the environment is discussed here.

Keywords

Quorum sensing N-acyl homoserine lactones Inhibition Reporter strains 

Notes

Acknowledgement

We are grateful to Prof. Robert JC McLean, Texas State University, USA, for his critical suggestions in the preparation of this manuscript. We would also like to acknowledge University Grants Commission, New Delhi for financial assistance in the form of a major research project.

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Iqbal Ahmad
  • Mohd Sajjad Ahmad Khan
    • 1
    Email author
  • Fohad Mabood Husain
  • Maryam Zahin
  • Mahipal Singh
  1. 1.Department of Agricultural Microbiology, Faculty of Agricultural SciencesAligarh Muslim UniversityAligarhIndia

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