Abstract
The genus Flavivirus contains approximately 70 viruses, and the major flaviviruses that cause human diseases are yellow fever virus (YFV), dengue virus (DV), West Nile virus (WNV), Japanese encephalitis virus (JEV), and tick-borne encephalitis virus [1]. The flaviviral particles contain single-stranded, positive-sensed RNA genome packaged within an icosahedral capsid formed by the capsid protein. The genome-containing capsid is surrounded by a host-derived lipid bilayer bearing dimers of the viral envelope protein and the membrane protein. The sizes of flavivirus virions are approximately 37–50 nm. Thus, the antigenic, genetic, and three-dimensional structures of all the flaviviruses are similar to each other.
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Acknowledgments
This work is supported mainly by the National Research Program for Genomic Medicine, National Science Council, Taiwan (NSC-95-3112-B-010-0171 & NSC 96-3112-B-010-2), and in part by the National Yang-Ming University, Taiwan (96A-D-D132 from MOE), the Taipei Veterans General Hospital (V97S5-001), and Academia Sinica.
We are grateful to the resources and collaborative efforts provided by the RNAi Consortium, Academia Sinica, Taiwan, and the Consortium for Functional Glycomics, funded by NIGMS-GM62116 USA.
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Chen, ST., Lin, YL., Huang, MT., Wu, MF., Hsieh, SL. (2011). Targeting C-Type Lectin for the Treatment of Flavivirus Infections. In: Wu, A. (eds) The Molecular Immunology of Complex Carbohydrates-3. Advances in Experimental Medicine and Biology, vol 705. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7877-6_40
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DOI: https://doi.org/10.1007/978-1-4419-7877-6_40
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