Microenvironmental Regulation of Tumor Angiogenesis: Biological and Engineering Considerations

  • David W. Infanger
  • Siddharth P. Pathi
  • Claudia Fischbach
Chapter

Abstract

Tumor angiogenesis is fundamental to tumor growth and metastasis, and antiangiogenic therapies have been developed to target this process. However, the clinical success of these treatments has been limited, which may be due, in part, to an incomplete understanding of cell–microenvironment interactions and their role in tumor angiogenesis. Traditionally, two-dimensional (2D) culture approaches have been used to study tumor progression in vitro, but these systems fail to faithfully recreate tumor microenvironmental conditions contributing to tumor angiogenesis in vivo. By integrating cancer biology with tissue engineering and drug delivery approaches, the development of biologically inspired tumor models has emerged. Such 3D model systems allow studying the specific role of soluble factor signaling, cell–extracellular matrix (ECM) interactions, cell–cell interactions, mechanical cues, and metabolic stress. This chapter discusses specific biological and engineering design considerations for tissue-engineered tumor models and highlights their application for defining the underpinnings of tumor angiogenesis.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • David W. Infanger
  • Siddharth P. Pathi
  • Claudia Fischbach
    • 1
  1. 1.Department of Biomedical EngineeringCornell UniversityIthacaUSA

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