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Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor

  • Chapter
Regulation of microRNAs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 700))

Abstract

The maturation of primary microrRNAs (pri-miRNAs) to precursor miRNAs (pre-miRNAs) is mediated by the “microprocessor” complex minimally comprimising two core components, Drosha and DGCR8. However, the roles of RNA-binding proteins associated with these core units in the large Drosha complex remain to be defined. While signal-dependent regulation of miRNA biogenesis is assumed, such regulation remains to be described. here, we provide a short review based on our recent findings of hormonally-regulated pri-miRNA processing by nuclear estrogen receptor.

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Authors and Affiliations

  1. Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo, 113-0032, Japan

    Shigeaki Kato

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  1. Sally Fujiyama-Nakamura
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  2. Kaoru Yamagata
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  3. Shigeaki Kato
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  1. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

    Helge Großhans

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Fujiyama-Nakamura, S., Yamagata, K., Kato, S. (2010). Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor. In: Großhans, H. (eds) Regulation of microRNAs. Advances in Experimental Medicine and Biology, vol 700. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7823-3_5

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