Part of the Springer Theses book series (Springer Theses)


We now know that almost every major biological process is controlled by protein assemblies composed of two or more proteins that interact with one another to exert their regulatory function [1]. These assemblies are called protein machineries because the way that they work at a microscopic scale resembles the way that machines work at a macroscopic scale. Underlying these highly controlled activities are the ordered conformational changes that take place in the protein components of the machineries. These conformational changes often lead to molecular events that drive efficient regulation of the biological processes.


Hydrolysis Polypeptide Triphosphate Diphosphate Guanosine 


  1. 1.
    Alberts B (1998) Cell 92:291CrossRefGoogle Scholar
  2. 2.
    Walter P, Johnson AE (1994) Annu Rev Cell Biol 10:87CrossRefGoogle Scholar
  3. 3.
    Shan SO, Schmid SL, Zhang X (2009) Biochem 48:6696CrossRefGoogle Scholar
  4. 4.
    Zhang X, Kung S, Shan SO (2008) J Mol Biol 381:581CrossRefGoogle Scholar
  5. 5.
    Zhang X, Schaffitzel C, Ban N, Shan SO (2009) Proc Natl Acad Sci U S A 106:1754CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.The Scripps Research InstituteLa JollaUSA

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